Histamine H4 receptor in oral lichen planus

A Salem; A Al‐Samadi; V Stegajev; H Stark; R Häyrinen‐Immonen; M Ainola; J Hietanen; YT Konttinen

doi:10.1111/odi.12290

journal article Oct 08, 2014

Histamine H4 receptor in oral lichen planus

A Salem A Al‐Samadi V Stegajev H Stark R Häyrinen‐Immonen M Ainola J Hietanen YT Konttinen

Oral Diseases Vol. 21 No. 3 pp. 378-385 · Wiley

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Abstract

ObjectivesOral lichen planus (OLP) is an autoimmune disease characterized by a band‐like T‐cell infiltrate below the apoptotic epithelial cells and degenerated basement membrane. We tested the hypothesis that the high‐affinity histamine H4 receptors (H4Rs) are downregulated in OLP by high histamine concentrations and proinflammatory T‐cell cytokines.Materials and MethodsImmunohistochemistry and immunofluorescence staining, image analysis and quantitative real‐time polymerase chain reaction of tissue samples and cytokine‐stimulated cultured SCC‐25 and primary human oral keratinocytes.ResultsH4R immunoreactivity was weak in OLP and characterized by mast cell (MC) hyperplasia and degranulation. In contrast to controls, H4R immunostaining and MC counts were negatively correlated in OLP (P = 0.003). H4R agonist at nanomolar levels led to a rapid internalization of H4Rs, whereas high histamine concentration and interferon‐γ decreased HRH4‐gene transcripts.ConclusionHealthy oral epithelial cells are equipped with H4R, which displays a uniform staining pattern in a MC‐independent fashion. In contrast, in OLP, increased numbers of activated MCs associate with increasing loss of epithelial H4R. Cell culture experiments suggest a rapid H4R stimulation‐dependent receptor internalization and a slow cytokine‐driven decrease in H4R synthesis. H4R may be involved in the maintenance of healthy oral mucosa. In OLP, this maintenance might be impaired by MC degranulation and inflammatory cytokines.

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Details

Published: Oct 08, 2014
Vol/Issue: 21(3)
Pages: 378-385
License: View

Authors

A

A Salem

Department of Medicine University of Helsinki and Helsinki University Central Hospital Helsinki Finland; Department of Oral Pathology University of Helsinki Helsinki Finland

A

A Al‐Samadi

Department of Medicine University of Helsinki and Helsinki University Central Hospital Helsinki Finland; Department of Oral Pathology University of Helsinki Helsinki Finland

V

V Stegajev

Department of Medicine University of Helsinki and Helsinki University Central Hospital Helsinki Finland

H

H Stark

Institut für Pharmazeutische und Medizinische Chemie Heinrich‐Heine‐Universität Düsseldorf Düsseldorf Germany

R

R Häyrinen‐Immonen

City of Helsinki Health Care Centre Helsinki Finland

M

M Ainola

Department of Medicine University of Helsinki and Helsinki University Central Hospital Helsinki Finland

J

J Hietanen

Department of Oral Pathology University of Helsinki Helsinki Finland; HUSLAB Helsinki University Central Hospital Helsinki Finland

Y

YT Konttinen

Department of Medicine University of Helsinki and Helsinki University Central Hospital Helsinki Finland; ORTON Orthopedic Hospital of the Invalid Foundation Helsinki Finland

Cite This Article

A Salem, A Al‐Samadi, V Stegajev, et al. (2014). Histamine H4 receptor in oral lichen planus. Oral Diseases, 21(3), 378-385. https://doi.org/10.1111/odi.12290

Histamine H4 receptor in oral lichen planus

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