Role of lactoferrin and lactoferrin‐derived peptides in oral and maxillofacial diseases

K Velliyagounder; D Bahdila; S Pawar; DH Fine

doi:10.1111/odi.12868

journal article Jun 07, 2018

Role of lactoferrin and lactoferrin‐derived peptides in oral and maxillofacial diseases

K Velliyagounder

D Bahdila S Pawar DH Fine

Oral Diseases Vol. 25 No. 3 pp. 652-669 · Wiley

View at Publisher Save 10.1111/odi.12868

Abstract

The oral cavity harbors different taxonomic groups, the evolutionary coexistence of which develops the oral ecosystem. These resident microorganisms can alter the balance between the physiologic and pathologic conditions that affect the host, both locally and systemically. This highly sophisticated nature of the oral cavity poses a significant therapeutic challenge. Numerous human and animal studies have been conducted to potentiate the efficacy and competence of current treatments of pathologic conditions as well as to develop novel therapeutic modalities. One of these studies is the use of the potent antimicrobial agent lactoferrin (LF), which was originally derived from the host immune system. LF is an 80‐kDa glycoprotein that has a free iron sequestration mechanism with evident antimicrobial, anti‐tumor, and immunomodulatory properties. A wide range of active peptides have been isolated from the N‐terminal region of LF, which possess antimicrobial activities. In this review, we discuss the role of LF and LF‐derived peptides under a heterogeneous group of oral and maxillofacial conditions, including bacterial, fungal, viral infections; head and neck cancers; xerostomia; and implantology‐bone‐related manifestations.

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Details

Published: Jun 07, 2018
Vol/Issue: 25(3)
Pages: 652-669
License: View

Authors

K

K Velliyagounder

Department of Oral Biology Rutgers School of Dental Medicine Newark New Jersey

D

D Bahdila

Department of Oral Biology Rutgers School of Dental Medicine Newark New Jersey

S

S Pawar

Department of Oral Biology Rutgers School of Dental Medicine Newark New Jersey

D

DH Fine

Department of Oral Biology Rutgers School of Dental Medicine Newark New Jersey

Cite This Article

K Velliyagounder, D Bahdila, S Pawar, et al. (2018). Role of lactoferrin and lactoferrin‐derived peptides in oral and maxillofacial diseases. Oral Diseases, 25(3), 652-669. https://doi.org/10.1111/odi.12868

Role of lactoferrin and lactoferrin‐derived peptides in oral and maxillofacial diseases

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