Salivary changes in oxidative stress related to inflammation in oral and gastrointestinal diseases

Katarína Janšáková; Michael Escudier; Ľubomíra Tóthová; Gordon Proctor

doi:10.1111/odi.13537

journal article Jul 30, 2020

Salivary changes in oxidative stress related to inflammation in oral and gastrointestinal diseases

Katarína Janšáková

Michael Escudier Ľubomíra Tóthová

Gordon Proctor

Oral Diseases Vol. 27 No. 2 pp. 280-289 · Wiley

View at Publisher Save 10.1111/odi.13537

Abstract

AbstractObjectivesThe early diagnosis and monitoring of Crohn's disease (CD) and orofacial granulomatosis (OFG) might be facilitated by assaying potential disease biomarkers in saliva. Markers of oxidative stress and inflammation were assayed in salivas from patients with CD, OFG and concurrent OFG and CD (OFG + CD).SubjectsUnstimulated whole mouth saliva was collected from 93 subjects, and immunoglobulin A (IgA), lactoferrin (LF) and myeloperoxidase (MPO) were determined by ELISA. Markers of oxidative stress and antioxidant status were assayed spectrophotometrically.ResultsImmunoglobulin A was significantly (p < .03) higher in experimental groups vs the control group. LF was significantly (p < .01) higher in OFG + CD compared to CTRL and CD. Ferric reducing antioxidant power was lower (p ≤ .009) in all experimental groups, and advanced glycation end products were higher (p ≤ .01) in CD and OFG + CD patients.ConclusionOxidative stress is increased in saliva in CD and OFG. Although MPO, a product of inflammatory cells, was not significantly increased, the other innate immune markers, IgA and LF, which are also secreted by salivary glands, were increased. This study suggests that saliva might be utilized in monitoring CD and OFG but further longitudinal studies focused on analysing a panel of salivary markers are needed.

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Metrics

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References

Details

Published: Jul 30, 2020
Vol/Issue: 27(2)
Pages: 280-289
License: View

Authors

K

Katarína Janšáková

Institute of Physiology Faculty of Medicine Comenius University Bratislava Slovakia; Institute of Molecular Biomedicine Faculty of Medicine Comenius University Bratislava Slovakia

M

Michael Escudier

Centre for Host Microbiome Interactions Faculty of Dentistry & Craniofacial Sciences King’s College London London UK

�

Ľubomíra Tóthová

Institute of Molecular Biomedicine Faculty of Medicine Comenius University Bratislava Slovakia

G

Gordon Proctor

Centre for Host Microbiome Interactions Faculty of Dentistry & Craniofacial Sciences King’s College London London UK

Funding

Ministry of Education Award: VEGA 1/

Cite This Article

Katarína Janšáková, Michael Escudier, Ľubomíra Tóthová, et al. (2020). Salivary changes in oxidative stress related to inflammation in oral and gastrointestinal diseases. Oral Diseases, 27(2), 280-289. https://doi.org/10.1111/odi.13537

Salivary changes in oxidative stress related to inflammation in oral and gastrointestinal diseases

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