Hormone Replacement Therapy Relieves Periodontitis by Inhibiting Alveolar Bone Loss and Inflammation

Ying Man; Jianyong Qin; Hongliang Qiu; Yiying Wang; Xinyue Zhang; Shengjie Yan

doi:10.1111/odi.15192

journal article Nov 06, 2024

Hormone Replacement Therapy Relieves Periodontitis by Inhibiting Alveolar Bone Loss and Inflammation

Ying Man Jianyong Qin Hongliang Qiu

Yiying Wang

Xinyue Zhang

Shengjie Yan

Oral Diseases Vol. 31 No. 4 pp. 1307-1316 · Wiley

View at Publisher Save 10.1111/odi.15192

Abstract

ABSTRACTObjectiveHormone replacement therapy (HRT) is a commonly used strategy for treating menopausal symptoms, while its relation with periodontitis remains unclear. This study aimed to explore the potential effects of HRT on periodontitis, mainly in aspects of bone loss and inflammation.MethodsThe alveolar bone height (ABH), alveolar bone thickness (ABT), and bone mineral density (BMD) were measured in menopausal women with periodontitis who had received HRT or had not received HRT by cone beam computed tomography. Based on a rat model of periodontitis, the alveolar bone loss was evaluated by micro‐computed tomography and bone‐related biochemical markers. The expression/levels of inflammatory markers were measured to reflect periodontal inflammation.ResultsAlthough the differences were not all significant in each premolars/molars, the mesial/distal ABH and buccal/lingual ABT were lower, and the mesial/distal BMD was higher in patients in the HRT group than those in the control group. In a rat model of periodontitis, the alveolar bone loss was relieved by HRT. Additionally, HRT significantly weakened the elevation of inflammatory markers, including TNF‐α, IL‐1β, and IL‐6 in periodontitis rats.ConclusionsHRT contributes to the remission of periodontitis by inhibiting alveolar bone loss and inflammation.

Topics

No keywords indexed for this article. Browse by subject →

References

47

[1]

10.4103/jpbs.jpbs_145_21

[2]

Alese M. O. "Progesterone Modulates Cadmium‐Induced Oxidative Stress and Inflammation in Hepatic Tissues of Wistar Rats" International Journal of Clinical and Experimental Pathology (2021)

[3]

Boschetti M. "Replacement Therapy and Cardiovascular Diseases" Journal of Endocrinological Investigation (2008)

[4]

10.1080/00325481.2018.1396876

[5]

10.1016/j.mcna.2022.10.003

[6]

10.17096/jiufd.61637

[7]

10.1002/iub.48

[8]

10.1111/odi.13059

[9]

10.1001/archinte.162.12.1409

[10]

10.3390/biom12091299

[11]

10.1016/j.molimm.2017.02.006

[12]

10.1016/j.semcdb.2021.05.014

[13]

10.1111/j.1600‐0757.2012.00457.x

[14]

10.1016/j.beem.2021.101551

[15]

10.1007/s10753‐020‐01390‐y

[16]

10.1016/j.maturitas.2016.10.005

[17]

10.1080/10408363.2021.1907298

[18]

10.1155/2022/8862278

[19]

10.1177/2515690x19829380

[20]

10.1177/0022034514552491

[21]

10.1016/j.jbiomech.2014.12.007

[22]

10.1016/j.pharmthera.2012.03.007

[23]

10.1177/154405910608500704

[24]

10.3390/cells8060537

[25]

López‐Marcos J. F. "Periodontal Aspects in Menopausal Women Undergoing Hormone Replacement Therapy" Medicina Oral, Patología Oral y Cirugía Bucal (2005)

[26]

10.1161/01.hyp.0000085560.02979.0c

[27]

10.1016/s0140‐6736(08)60346‐3

[28]

10.1007/978‐3‐030‐38474‐6_6

[29]

10.5051/jpis.2202480124

[30]

10.1097/gme.0000000000000830

[31]

10.12659/msm.881700

[32]

10.1111/prd.12047

[33]

10.1111/jcpe.13248

[34]

10.1016/s0755‐4982(05)83927‐2

[35]

10.1007/s00198‐020‐05497‐8

[36]

10.1111/j.1741‐2358.2011.00608.x

[37]

10.3109/13697137.2012.669530

[38]

10.1111/prd.12221

[39]

10.1007/s11033‐020‐05461‐z

[40]

10.1055/s-0034-1367031

[41]

10.4103/0976‐7800.141187

[42]

10.3390/biom12081029

[43]

10.1002/jper.18‐0006

[44]

10.3390/ijms24065814

[45]

10.1902/jop.2015.140533

[46]

10.1172/jci28550

[47]

10.1038/s41598‐017‐15285‐w

Cited By

2

Understanding the Link Between Hormonal Changes and Gingival Health in Women: A Review

Sidra Tul Muntaha Jawed, Khadeeja Tul Kubra Jawed · 2025

Cureus

Metrics

2

Citations

47

References

Details

Published: Nov 06, 2024
Vol/Issue: 31(4)
Pages: 1307-1316
License: View

Authors

Y

Ying Man