Lesion Formation in Cardiac Pulsed‐Field Ablation: Acute to Chronic Cellular Level Changes

Kara Garrott; Savannah Bifulco; David Ramirez; Brendan Koop

doi:10.1111/pace.15154

journal article Open Access Jan 27, 2025

Lesion Formation in Cardiac Pulsed‐Field Ablation: Acute to Chronic Cellular Level Changes

Kara Garrott

Savannah Bifulco David Ramirez

Brendan Koop

Pacing and Clinical Electrophysiology Vol. 49 No. 1 pp. 32-42 · Wiley

View at Publisher Save 10.1111/pace.15154

Abstract

ABSTRACT
As pulsed‐field ablation (PFA) emerges as a promising therapy for atrial arrhythmias, an understanding of the cellular injury to cardiac tissue is critical to evaluating and interpreting results for each PFA system. This review aims to detail the mechanism of cell death for PFA, compare the cell death mechanism to thermal ablation modalities, clarify common histology markers, detail the progression of PFA lesions from the acute, to subacute, to chronic maturation states, and discuss clinical indicators of PFA lesions.

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Details

Published: Jan 27, 2025
Vol/Issue: 49(1)
Pages: 32-42
License: View

Authors

K

Kara Garrott

Boston Scientific, Corporation: Electrophysiology Research & Development Arden Hills Minnesota USA

S

Savannah Bifulco

Boston Scientific, Corporation: Electrophysiology Research & Development Arden Hills Minnesota USA

D

David Ramirez

Boston Scientific, Corporation: Electrophysiology Research & Development Arden Hills Minnesota USA

B

Brendan Koop

Boston Scientific, Corporation: Electrophysiology Research & Development Arden Hills Minnesota USA

Cite This Article

Kara Garrott, Savannah Bifulco, David Ramirez, et al. (2025). Lesion Formation in Cardiac Pulsed‐Field Ablation: Acute to Chronic Cellular Level Changes. Pacing and Clinical Electrophysiology, 49(1), 32-42. https://doi.org/10.1111/pace.15154

Lesion Formation in Cardiac Pulsed‐Field Ablation: Acute to Chronic Cellular Level Changes

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