Clinical relevance of venlafaxine
                    ER
                    for generalized anxiety disorder

Itsuki Terao

doi:10.1111/pcn.13924

journal article Nov 19, 2025

Clinical relevance of venlafaxine ER for generalized anxiety disorder

Itsuki Terao

Psychiatry and Clinical Neurosciences Vol. 80 No. 4 pp. 358-358 · Wiley

View at Publisher Save 10.1111/pcn.13924

Abstract

A randomized, double‐blinded, placebo‐controlled study by Otsubo et al. demonstrated a statistically significant effect of venlafaxine in patients with generalized anxiety disorder. However, the magnitude of improvement may have little clinical value. Methodological factors—including the exclusion of placebo responders, the inclusion of participants with comorbid depressive disorders, and a higher rate of discontinuation due to adverse events—further diminish the clinical significance of the findings. Overall, although venlafaxine achieved statistical efficacy, it may lack a clinically meaningful risk–benefit balance.

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References

2

[1]

10.1111/pcn.13907

[2]

10.1016/j.jad.2020.01.032

Cited By

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Response to “Clinical relevance of venlafaxine ER for generalized anxiety disorder”

Tempei Otsubo, Koichiro Watanabe · 2026

Psychiatry and Clinical Neuroscienc...

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Details

Published: Nov 19, 2025
Vol/Issue: 80(4)
Pages: 358-358
License: View

Authors

I

Itsuki Terao

Department of Psychiatry Ikokoro Clinic Nihonbashi Tokyo Japan

Cite This Article

Itsuki Terao (2025). Clinical relevance of venlafaxine ER for generalized anxiety disorder. Psychiatry and Clinical Neurosciences, 80(4), 358-358. https://doi.org/10.1111/pcn.13924

Clinical relevance of venlafaxine ER for generalized anxiety disorder

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