Narrow‐band UVB phototherapy and psoralen–ultraviolet A photochemotherapy in the treatment of cutaneous mastocytosis: a study in 20 patients

Valeria Brazzelli; Sara Grassi; Serena Merante; Vincenzo Grasso; Rachele Ciccocioppo; Grazia Bossi; Giovanni Borroni

doi:10.1111/phpp.12248

journal article Jul 27, 2016

Narrow‐band UVB phototherapy and psoralen–ultraviolet A photochemotherapy in the treatment of cutaneous mastocytosis: a study in 20 patients

Valeria Brazzelli

Sara Grassi Serena Merante Vincenzo Grasso Rachele Ciccocioppo

Grazia Bossi Giovanni Borroni

Photodermatology, Photoimmunology & Photomedicine Vol. 32 No. 5-6 pp. 238-246 · Wiley

View at Publisher Save 10.1111/phpp.12248

Abstract

SummaryBackgroundIn mastocytosis, the skin is almost invariably involved, and cutaneous symptoms deeply affect patients' quality of life.MethodsA retrospective observational analysis of patients affected by cutaneous mastocytosis (CM) and indolent systemic mastocytosis (ISM) treated with phototherapy/photochemotherapy (PUVA or NB‐UVB) has been conducted. For each patient, total numbers of PUVA or NB‐UVB exposures, the cumulative UV dose (J/cm2), serum tryptase profile, and pruritus, before and after treatment, according to the visual analogue scale (VAS) were considered. Skin lesions of each patient were assessed, before and after treatment, according to a cutaneous scale score.ResultsTwenty patients affected by CM and ISM were studied; in particular, 10 patients received NB‐UVB therapy, and other 10 patients received PUVA. A statistically significant mean reduction of pruritus in both groups (P < 0.01) was observed. The number of treatments necessary to obtain symptom relief was significantly lower in the PUVA group, but the mean exposure dose was significantly higher, if compared to the NB‐UVB group. Serum tryptase levels showed a downward trend. The cutaneous score improved in both groups.LimitationsThis study was a retrospective study with a small sample size and without a control group.ConclusionThis work provides evidence that both NB‐UVB and PUVA represent a safe and useful second‐line therapy of the cutaneous symptoms in mastocytosis.

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References

Details

Published: Jul 27, 2016
Vol/Issue: 32(5-6)
Pages: 238-246
License: View

Authors

V

Valeria Brazzelli

Institute of Dermatology Department of Clinical‐Surgical, Diagnostic and Pediatric Science IRCCS Foundation Policlinico San Matteo University of Pavia Pavia Italy

S

Sara Grassi

Institute of Dermatology Department of Clinical‐Surgical, Diagnostic and Pediatric Science IRCCS Foundation Policlinico San Matteo University of Pavia Pavia Italy

S

Serena Merante

Department of Haematology IRCCS Foundation Policlinico San Matteo University of Pavia Pavia Italy

V

Vincenzo Grasso

Institute of Dermatology Department of Clinical‐Surgical, Diagnostic and Pediatric Science IRCCS Foundation Policlinico San Matteo University of Pavia Pavia Italy

R

Rachele Ciccocioppo

First Department of Internal Medicine IRCCS Foundation Policlinico San Matteo University of Pavia Pavia Italy

G

Grazia Bossi

Department of Pediatrics IRCCS Foundation Policlinico San Matteo University of Pavia Pavia Italy

G

Giovanni Borroni

Institute of Dermatology Department of Clinical‐Surgical, Diagnostic and Pediatric Science IRCCS Foundation Policlinico San Matteo University of Pavia Pavia Italy

Cite This Article

Valeria Brazzelli, Sara Grassi, Serena Merante, et al. (2016). Narrow‐band UVB phototherapy and psoralen–ultraviolet A photochemotherapy in the treatment of cutaneous mastocytosis: a study in 20 patients. Photodermatology, Photoimmunology & Photomedicine, 32(5-6), 238-246. https://doi.org/10.1111/phpp.12248

Narrow‐band UVB phototherapy and psoralen–ultraviolet A photochemotherapy in the treatment of cutaneous mastocytosis: a study in 20 patients

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