A sticky end for gastrointestinal helminths; the role of the mucus barrier

C. Sharpe; David J. Thornton; R. K. Grencis

doi:10.1111/pim.12517

journal article Open Access Mar 04, 2018

A sticky end for gastrointestinal helminths; the role of the mucus barrier

C. Sharpe

David J. Thornton

R. K. Grencis

Parasite Immunology Vol. 40 No. 4 · Wiley

View at Publisher Save 10.1111/pim.12517

Abstract

SummaryGastrointestinal (GI) nematodes are a group of successful multicellular parasites that have evolved to coexist within the intestinal niche of multiple species. It is estimated that over 10% of the world's population are chronically infected by GI nematodes, making this group of parasitic nematodes a major burden to global health. Despite the large number of affected individuals, there are few effective treatments to eradicate these infections. Research into GI nematode infections has primarily focused on defining the immunological and pathological consequences on host protection. One important but neglected aspect of host protection is mucus, and the concept that mucus is just a simple barrier is no longer tenable. In fact, mucus is a highly regulated and dynamic‐secreted matrix, underpinned by a physical hydrated network of highly glycosylated mucins, which is increasingly recognized to have a key protective role against GI nematode infections. Unravelling the complex interplay between mucins, the underlying epithelium and immune cells during infection are a major challenge and are required to fully define the protective role of the mucus barrier. This review summarizes the current state of knowledge on mucins and the mucus barrier during GI nematode infections, with particular focus on murine models of infection.

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Metrics

85

Citations

98

References

Details

Published: Mar 04, 2018
Vol/Issue: 40(4)
License: View

Authors

C

C. Sharpe

Manchester Immunology Group Wellcome Trust Centre for Cell‐Matrix Research Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK

D

David J. Thornton

Manchester Immunology Group Wellcome Trust Centre for Cell‐Matrix Research Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK

R

R. K. Grencis

Manchester Immunology Group Wellcome Trust Centre for Cell‐Matrix Research Faculty of Biology, Medicine and Health Manchester Academic Health Science Centre University of Manchester Manchester UK

Funding

Wellcome Trust Award: 203128/Z/16/Z

Biotechnology and Biological Sciences Research Council

Cite This Article

C. Sharpe, David J. Thornton, R. K. Grencis (2018). A sticky end for gastrointestinal helminths; the role of the mucus barrier. Parasite Immunology, 40(4). https://doi.org/10.1111/pim.12517

A sticky end for gastrointestinal helminths; the role of the mucus barrier

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