fMRI BOLD responses to film stimuli and their association with exhaled nitric oxide in asthma and health

Thomas Ritz; Juliet L. Kroll; David A. Khan; Uma S. Yezhuvath; Sina Aslan; Amy Pinkham; David Rosenfield; E. Sherwood Brown

doi:10.1111/psyp.14513

journal article Feb 10, 2024

fMRI BOLD responses to film stimuli and their association with exhaled nitric oxide in asthma and health

Thomas Ritz

Juliet L. Kroll

David A. Khan Uma S. Yezhuvath Sina Aslan Amy Pinkham David Rosenfield E. Sherwood Brown

Psychophysiology Vol. 61 No. 5 · Wiley

View at Publisher Save 10.1111/psyp.14513

Abstract

AbstractLittle is known about central nervous system (CNS) responses to emotional stimuli in asthma. Nitric oxide in exhaled breath (FENO) is elevated in asthma due to allergic immune processes, but endogenous nitric oxide is also known to modulate CNS activity. We measured fMRI blood oxygen‐dependent (BOLD) brain activation to negative (blood–injection–injury themes) and neutral films in 31 participants (15 with asthma). Regions‐of‐interest analysis was performed on key areas relevant to central adaptive control, threat processing, or salience networks, with dorsolateral prefrontal cortex (PFC), anterior insula, dorsal anterior cingulate cortex (dACC), amygdala, ventral striatum, ventral tegmentum, and periaqueductal gray, as well as top‐down modulation of emotion, with ventrolateral and ventromedial PFC. Both groups showed less BOLD deactivation from fixation cross‐baseline in the left anterior insula and bilateral ventromedial PFC for negative than neutral films, and for an additional number of areas, including the fusiform gyrus, for film versus recovery phases. Less deactivation during films followed by less recovery from deactivation was found in asthma compared to healthy controls. Changes in PCO2 did not explain these findings. FENO was positively related to BOLD activation in general, but more pronounced in healthy controls and more likely in neutral film processing. Thus, asthma is associated with altered processing of film stimuli across brain regions not limited to central adaptive control, threat processing, or salience networks. Higher levels of NO appear to facilitate CNS activity, but only in healthy controls, possibly due to allergy's masking effects on FENO.

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Details

Published: Feb 10, 2024
Vol/Issue: 61(5)
License: View

Authors

T

Thomas Ritz

Department of Psychology Southern Methodist University Dallas Texas USA

J

Juliet L. Kroll

Department of Psychology Southern Methodist University Dallas Texas USA; Department of Palliative, Rehabilitation and Integrative Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA

D

David A. Khan

Department of Internal Medicine, Division of Allergy and Immunology The University of Texas Southwestern Medical Center Dallas Texas USA

U

Uma S. Yezhuvath

Advance MRI LLC Frisco Texas USA

S

Sina Aslan

Department of Internal Medicine, Division of Allergy and Immunology The University of Texas Southwestern Medical Center Dallas Texas USA; Advance MRI LLC Frisco Texas USA; Department of Psychology University of Texas at Dallas Dallas Texas USA

A

Amy Pinkham

Department of Psychology University of Texas at Dallas Dallas Texas USA

D

David Rosenfield

Department of Psychology Southern Methodist University Dallas Texas USA

E

E. Sherwood Brown

Department of Psychiatry The University of Texas Southwestern Medical Center Dallas Texas USA

Cite This Article

Thomas Ritz, Juliet L. Kroll, David A. Khan, et al. (2024). fMRI BOLD responses to film stimuli and their association with exhaled nitric oxide in asthma and health. Psychophysiology, 61(5). https://doi.org/10.1111/psyp.14513

fMRI BOLD responses to film stimuli and their association with exhaled nitric oxide in asthma and health

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