A new equation to estimate temperature‐corrected PaCO2 from PETCO2 during exercise in normoxia and hypoxia

J. J. González Henríquez; J. Losa‐Reyna; R. Torres‐Peralta; G. Rådegran; M. Koskolou; J. A. L. Calbet

doi:10.1111/sms.12545

journal article Aug 27, 2015

A new equation to estimate temperature‐corrected PaCO2 from PETCO2 during exercise in normoxia and hypoxia

J. J. González Henríquez J. Losa‐Reyna R. Torres‐Peralta G. Rådegran M. Koskolou J. A. L. Calbet

Scandinavian Journal of Medicine & Science in Sports Vol. 26 No. 9 pp. 1045-1051 · Wiley

View at Publisher Save 10.1111/sms.12545

Abstract

End‐tidal PCO2 (PETCO2) has been used to estimate arterial pressure CO2 (PaCO2). However, the influence of blood temperature on the PaCO2 has not been taken into account. Moreover, there is no equation validated to predict PaCO2 during exercise in severe acute hypoxia. To develop a new equation to predict temperature‐corrected PaCO2 values during exercise in normoxia and severe acute hypoxia, 11 volunteers (21.2 ± 2.1 years) performed incremental exercise to exhaustion in normoxia (Nox, PIO2: 143 mmHg) and hypoxia (Hyp, PIO2: 73 mmHg), while arterial blood gases and temperature (ABT) were simultaneously measured together with end‐tidal PCO2 (PETCO2). The Jones et al. equation tended to underestimate the temperature corrected (tc) PaCO2 during exercise in hypoxia, with greater deviation the lower the PaCO2tc (r = 0.39, P < 0.05). The new equation has been developed using a random‐effects regression analysis model, which allows predicting PaCO2tc both in normoxia and hypoxia: PaCO2tc = 8.607 + 0.716 × PETCO2 [R2 = 0.91; intercept SE = 1.022 (P < 0.001) and slope SE = 0.027 (P < 0.001)]. This equation may prove useful in noninvasive studies of brain hemodynamics, where an accurate estimation of PaCO2 is needed to calculate the end‐tidal‐to‐arterial PCO2 difference, which can be used as an index of pulmonary gas exchange efficiency.

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References

20

[1]

10.1113/jphysiol.1985.sp015794

[2]

10.1152/japplphysiol.00686.2014

[3]

10.1113/jp270408

[4]

10.1152/ajpregu.00746.2005

[5]

10.1111/sms.12473

[6]

10.1111/sms.12273

[7]

10.1152/jappl.1988.64.4.1721

[8]

10.1161/01.cir.0000049746.29175.3f

[9]

10.1152/jappl.1979.47.5.954

[10]

10.1111/sms.12345

[11]

Koskolou MD "Hypoxia and the cardiovascular response to dynamic knee‐extensor exercise" Am J Physiol (1997)

[12]

Cardiovascular responses to dynamic exercise with acute anemia in humans

Maria D. Koskolou, Robert C. Roach, José A. L. Calbet et al.

American Journal of Physiology-Heart and Circulato... 10.1152/ajpheart.1997.273.4.h1787

[13]

10.14814/phy2.12512

[14]

10.1113/jp270487

[15]

A general and simple method for obtaining R 2 from generalized linear mixed‐effects models

Shinichi Nakagawa, Holger Schielzeth

Methods in Ecology and Evolution 10.1111/j.2041-210x.2012.00261.x

[16]

10.1111/sms.12379

[17]

10.1152/ajpheart.1999.276.2.h438

[18]

10.1152/jappl.1990.68.4.1727

[19]

10.1152/jappl.1979.46.3.599

[20]

Siggaard‐Andersen O (1974)

Metrics

9

Citations

20

References

Details

Published: Aug 27, 2015
Vol/Issue: 26(9)
Pages: 1045-1051
License: View

Authors

J

J. J. González Henríquez

Department of Mathematics University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Canary Islands Spain; Research Institute of Biomedical and Health Sciences (IUIBS) University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Canary Islands Spain

J

J. Losa‐Reyna

Research Institute of Biomedical and Health Sciences (IUIBS) University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Canary Islands Spain; Department of Physical Education University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Canary Islands Spain

R

R. Torres‐Peralta

Research Institute of Biomedical and Health Sciences (IUIBS) University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Canary Islands Spain; Department of Physical Education University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Canary Islands Spain

G

G. Rådegran

Department of Clinical Sciences Lund Cardiology Lund University Lund Sweden; The Haemodynamic Laboratory The Section for Heart Failure and Valvular Disease The Clinic for Heart and Lung Disease Skåne University Hospital Lund Sweden

M

M. Koskolou

Faculty of Physical Education and Sport Science National and Kapodistrian University of Athens Athens Greece

J

J. A. L. Calbet

Research Institute of Biomedical and Health Sciences (IUIBS) University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Canary Islands Spain; Department of Physical Education University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Canary Islands Spain

Funding

Federación Española de Enfermedades Raras

Cite This Article

J. J. González Henríquez, J. Losa‐Reyna, R. Torres‐Peralta, et al. (2015). A new equation to estimate temperature‐corrected PaCO2 from PETCO2 during exercise in normoxia and hypoxia. Scandinavian Journal of Medicine & Science in Sports, 26(9), 1045-1051. https://doi.org/10.1111/sms.12545

A new equation to estimate temperature‐corrected PaCO2 from PETCO2 during exercise in normoxia and hypoxia

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