The role of topical capsaicin gel in pain management during microfocused ultrasound treatment for neck laxity

Vasanop Vachiramon; Pansakorn Tanratana; Tanaporn Anuntrangsee; Pasita Palakornkitti; Nitina Yeesibsean; Pintusorn Kungvalpivat; Sabrina Fabi

doi:10.1111/srt.13240

journal article Open Access Nov 16, 2022

The role of topical capsaicin gel in pain management during microfocused ultrasound treatment for neck laxity

Vasanop Vachiramon

Pansakorn Tanratana Tanaporn Anuntrangsee Pasita Palakornkitti Nitina Yeesibsean Pintusorn Kungvalpivat Sabrina Fabi

Skin Research and Technology Vol. 29 No. 1 · Wiley

View at Publisher Save 10.1111/srt.13240

Abstract

AbstractBackgroundThe transient receptor potential vanilloid 1 (TRPV1) provides a heat and pain sensation (nociception). Capsaicin, a TRPV1 agonist, has been shown to induce a refractory period in the nerve terminal expressing TRPV1 and create long‐term nerve terminal defunctionalization.ObjectiveTo evaluate the efficacy of capsaicin for pain reduction during microfocused ultrasound with visualization (MFU‐V) treatment.Methods and materialsA randomized, split‐side study including 24 subjects was conducted. A combined 0.025% capsaicin gel and topical anesthetic were randomly applied on one side of the neck, and a topical anesthetic monotherapy was applied on the contralateral side for 30 min before MFU‐V treatment. Pain score (visual analog scale, 0–10) was evaluated at T1 (before MFU‐V), T2a (after the 4.5‐mm transducer treatment), T2b (after the 3.0‐mm transducer treatment), and T3 (after the entire treatment). Side effects were recorded.ResultsMean pain scores at T2a for combined and single regimens were 5.19 (±2.26) and 6.91 (±1.72), respectively (p < 0.001). The capsaicin‐treated side had a lower pain score at T2b and T3 (p < 0.001). Redness was longer on the capsaicin‐treated side (112.67 vs. 10.68 min, p < 0.001). No other adverse events including contact dermatitis were reported.ConclusionA single application of a combined 0.025% capsaicin gel with topical anesthesia produces a significantly lesser pain score during the MFU‐V treatment. Defunctionalization of TRPV1 may explain the alleviation of painful sensations caused by heat from MFU‐V.

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Details

Published: Nov 16, 2022
Vol/Issue: 29(1)
License: View

Authors

V

Vasanop Vachiramon

Division of Dermatology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand

P

Pansakorn Tanratana

Department of Pharmacology Faculty of Science Mahidol University Bangkok Thailand

T

Tanaporn Anuntrangsee

Division of Dermatology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand

P

Pasita Palakornkitti

Division of Dermatology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand

N

Nitina Yeesibsean

Division of Dermatology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand; Division of Dermatology Department of Medicine, Faculty of Medicine Naresuan University Phitsanulok Thailand

P

Pintusorn Kungvalpivat

Division of Dermatology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand

S

Sabrina Fabi

Cosmetic Laser Dermatology San Diego California USA; University of California San Diego California USA

Cite This Article

Vasanop Vachiramon, Pansakorn Tanratana, Tanaporn Anuntrangsee, et al. (2022). The role of topical capsaicin gel in pain management during microfocused ultrasound treatment for neck laxity. Skin Research and Technology, 29(1). https://doi.org/10.1111/srt.13240

The role of topical capsaicin gel in pain management during microfocused ultrasound treatment for neck laxity

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