Concurrent cytomegalovirus glomerulitis and BK polyomavirus‐associated nephropathy in a kidney allograft biopsy

I.O. Chikeka; A. Paulk; A. Haririan; J.C. Papadimitriou; C.B. Drachenberg

doi:10.1111/tid.12498

journal article Feb 22, 2016

Concurrent cytomegalovirus glomerulitis and BK polyomavirus‐associated nephropathy in a kidney allograft biopsy

I.O. Chikeka A. Paulk A. Haririan J.C. Papadimitriou C.B. Drachenberg

Transplant Infectious Disease Vol. 18 No. 2 pp. 247-250 · Wiley

View at Publisher Save 10.1111/tid.12498

Abstract

AbstractA 58‐year‐old renal transplant recipient underwent biopsy 11 weeks post transplantation for increasing creatinine. The biopsy showed cytomegalovirus (CMV) glomerulitis together with BK polyomavirus (BKPyV)‐associated nephropathy (PVAN). Treatment with intravenous ganciclovir and overall reduction in maintenance immunosuppression resulted in prompt resolution of the CMV glomerulitis, but with persistence of PVAN in a follow‐up biopsy 4 weeks later. Stable creatinine and BKPyV viral clearance were observed at the last clinical visit 15 months post transplantation. This case exemplifies infectious glomerulitis, which requires differentiation from the more common glomerulitis caused by antibody‐mediated allograft rejection. The morphological similarities and differences between BKPyV and CMV infections are discussed.

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Citations

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References

Details

Published: Feb 22, 2016
Vol/Issue: 18(2)
Pages: 247-250
License: View

Authors

I

I.O. Chikeka

Department of Pathology University of Maryland School of Medicine Baltimore Maryland USA

A

A. Paulk

Department of Pathology University of Maryland School of Medicine Baltimore Maryland USA

A

A. Haririan

Department of Medicine University of Maryland School of Medicine Baltimore Maryland USA

J

J.C. Papadimitriou

Department of Pathology University of Maryland School of Medicine Baltimore Maryland USA

C

C.B. Drachenberg

Department of Pathology University of Maryland School of Medicine Baltimore Maryland USA

Cite This Article

I.O. Chikeka, A. Paulk, A. Haririan, et al. (2016). Concurrent cytomegalovirus glomerulitis and BK polyomavirus‐associated nephropathy in a kidney allograft biopsy. Transplant Infectious Disease, 18(2), 247-250. https://doi.org/10.1111/tid.12498

Concurrent cytomegalovirus glomerulitis and BK polyomavirus‐associated nephropathy in a kidney allograft biopsy

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