Incidence, Risk Factors, and Clinical Outcomes of Active Tuberculosis in Kidney Transplant Recipients From Romania: A Single‐Center Study

Bogdan Marian Sorohan; Dorina Tacu; Cristina Bucșa; Andreea Asavei; Teodora Crăciun; Nicoleta Borboșanu; George Dimofte; Gîngu Constantin; Gina Ciolan; Bogdan Obrișcă; Gener Ismail; Oana‐Mădălina Baston

doi:10.1111/tid.70156

journal article Dec 22, 2025

Incidence, Risk Factors, and Clinical Outcomes of Active Tuberculosis in Kidney Transplant Recipients From Romania: A Single‐Center Study

Bogdan Marian Sorohan Dorina Tacu Cristina Bucșa Andreea Asavei Teodora Crăciun Nicoleta Borboșanu George Dimofte Gîngu Constantin Gina Ciolan Bogdan Obrișcă Gener Ismail Oana‐Mădălina Baston

Transplant Infectious Disease Vol. 28 No. 2 · Wiley

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Abstract

ABSTRACT

Background
The present study aimed to assess the incidence of active TB, risk factors associated with TB and KT outcomes among a group of KTR from Romania.

Methods
This single‐center, nested case‐control study, included 22 KTR with active TB and 88 KTR without active TB (matched 1:4) identified from 1485 patients who underwent KT at Fundeni Clinical Institute between 2002 and 2017.

Results

The incidence of active TB among the cohort was 1.48% with a median time to occurrence of 60.26 months (IQR: 30.75–102.50) after KT. Multivariate conditional logistic regression showed that history of active TB before KT (OR = 17.97 [95% CI: 1.35–238.22],
p
= 0.02) and anti‐thymocyte globulin induction (OR = 2.14 [95% CI: 1.10–4.24],
p
= 0.02) were independent risk factors associated with TB development. Patient survival (
p
= 0.03), overall (
p
< 0.001) and death‐censored graft survival (
p
< 0.001) were significantly lower in KTR with active TB than in controls during the follow‐up period. Kidney function was not significantly different between TB cases and controls at the last follow‐up (
p
= 0.57) in an adjusted analysis.

Conclusion
This study was the first to evaluate active TB in KTR from Romania and found a higher incidence of active TB than that in the general population and a late onset of infection. TB had a negative impact on both patient and graft survival. Screening for latent TB, judicious prophylaxis, rigorous monitoring after KT and tailoring of the immunosuppression could be effective strategies to reduce the burden of TB among KTR.

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Details

Published: Dec 22, 2025
Vol/Issue: 28(2)
License: View

Authors

B

Bogdan Marian Sorohan

Carol Davila University of Medicine and Pharmacy Bucharest Romania; Department of Kidney Transplantation Fundeni Clinical Institute Bucharest Romania

D

Dorina Tacu

Department of Kidney Transplantation Fundeni Clinical Institute Bucharest Romania

C

Cristina Bucșa

Department of Kidney Transplantation Fundeni Clinical Institute Bucharest Romania

A

Andreea Asavei

Department of Nephrology Fundeni Clinical Institute Bucharest Romania

T

Teodora Crăciun

Department of Nephrology Fundeni Clinical Institute Bucharest Romania

N

Nicoleta Borboșanu

Department of Nephrology Constanța County Emergency Clinical Hospital Constanța Romania

G

George Dimofte

Department of Nephrology Fundeni Clinical Institute Bucharest Romania

G

Gîngu Constantin

Carol Davila University of Medicine and Pharmacy Bucharest Romania; Department of Kidney Transplantation Fundeni Clinical Institute Bucharest Romania

G

Gina Ciolan

Department of Pneumology Marius Nasta Institute of Pneumology Bucharest Romania

B

Bogdan Obrișcă

Carol Davila University of Medicine and Pharmacy Bucharest Romania; Department of Nephrology Fundeni Clinical Institute Bucharest Romania

G

Gener Ismail

Carol Davila University of Medicine and Pharmacy Bucharest Romania; Department of Nephrology Fundeni Clinical Institute Bucharest Romania

O

Oana‐Mădălina Baston

Carol Davila University of Medicine and Pharmacy Bucharest Romania; Department of Radiology Medical Imaging and Interventional Radiology Dr. Carol Davila Central Military Emergency University Hospital Bucharest Romania

Cite This Article

Bogdan Marian Sorohan, Dorina Tacu, Cristina Bucșa, et al. (2025). Incidence, Risk Factors, and Clinical Outcomes of Active Tuberculosis in Kidney Transplant Recipients From Romania: A Single‐Center Study. Transplant Infectious Disease, 28(2). https://doi.org/10.1111/tid.70156

Incidence, Risk Factors, and Clinical Outcomes of Active Tuberculosis in Kidney Transplant Recipients From Romania: A Single‐Center Study

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