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journal article Nov 20, 2019

Hepatitis B and C in the adult population of Bissau, Guinea‐Bissau: a cross‐sectional survey

Bo Langhoff Hønge Jens Steen Olesen Mads Mose Jensen Sanne Jespersen Zacarias José da Silva Amabélia Rodrigues Alex Lund Laursen Christian Wejse ORCID Henrik Krarup Peter Aaby Christian Erikstrup ORCID
Tropical Medicine & International Health Vol. 25 No. 2 pp. 255-263 · Wiley
View at Publisher Save 10.1111/tmi.13335
Abstract
AbstractObjectiveHepatitis B virus (HBV) and hepatitis C virus (HCV) are prevalent in West Africa. To address the WHO 2030 goals of a 90% reduction in incidence and a 65% reduction in mortality for both infections, we assessed the prevalence of HBV and HCV from surveys in the general population.MethodsParticipants in this cross‐sectional survey were included from randomly selected houses in a demographic surveillance site in Bissau, Guinea‐Bissau. Participants were interviewed and had a blood sample drawn for viral analyses (HBsAg, anti‐HBs, anti‐HBc, anti‐HCV and HCV RNA). Risk factors of HBV and HCV infection were determined by binomial regression adjusted for sex and age.ResultsA total of 2715 participants were included in this study. The overall HBsAg prevalence was 18.7% (95% CI: 17.3–20.2%). HBsAg was associated with male sex (adjusted risk ratio (aRR): 1.64), and prevalence decreased with age >34 years. HBV exposure was found in 91.9% of participants. Although 72.6% of individuals without sexual debut had been exposed to HBV, ever engaging in a sexual relationship was associated with higher risk of HBV exposure (aRR 1.18). The anti‐HCV prevalence was 0.5% (95% CI: 0.3–0.9%), and 78.6% of those had detectable HCV RNA. Risk factors for anti‐HCV sero‐positivity were age above 55 (aRR 10.60), a history of blood transfusion (aRR 5.07) and being in a polygamous marriage (aRR 3.52).ConclusionIn Guinea‐Bissau initiatives to implement treatment and widespread testing are needed to reach the WHO 2030 goals.
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Metrics
13
Citations
56
References
Details
Published
Nov 20, 2019
Vol/Issue
25(2)
Pages
255-263
License
View
Authors
B
Bo Langhoff Hønge

Bandim Health Project Indepth Network Bissau Guinea‐Bissau; Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark; Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark

J
Jens Steen Olesen

Bandim Health Project Indepth Network Bissau Guinea‐Bissau; Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark

M
Mads Mose Jensen

Bandim Health Project Indepth Network Bissau Guinea‐Bissau; Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark

S
Sanne Jespersen

Bandim Health Project Indepth Network Bissau Guinea‐Bissau; Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark

Z
Zacarias José da Silva

Bandim Health Project Indepth Network Bissau Guinea‐Bissau; National Public Health Laboratory Bissau Guinea‐Bissau

A
Amabélia Rodrigues

Bandim Health Project Indepth Network Bissau Guinea‐Bissau

A
Alex Lund Laursen

Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark

C
Christian Wejse

Bandim Health Project Indepth Network Bissau Guinea‐Bissau; Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark; GloHAU Center for Global Health School of Public Health Aarhus University Aarhus Denmark

H
Henrik Krarup

Section of Molecular Diagnostics Clinical Biochemistry Aalborg University Hospital Aalborg Denmark

P
Peter Aaby

Bandim Health Project Indepth Network Bissau Guinea‐Bissau

C
Christian Erikstrup

Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark

Funding
Aase og Ejnar Danielsens Fond
Cite This Article
Bo Langhoff Hønge, Jens Steen Olesen, Mads Mose Jensen, et al. (2019). Hepatitis B and C in the adult population of Bissau, Guinea‐Bissau: a cross‐sectional survey. Tropical Medicine & International Health, 25(2), 255-263. https://doi.org/10.1111/tmi.13335
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