Molecular Mechanisms Involved in Antibody‐Dependent Enhancement of Dengue Virus Infection in Humans

Jacky Flipse; Jan Wilschut; Jolanda M. Smit

doi:10.1111/tra.12012

journal article Open Access Oct 22, 2012

Molecular Mechanisms Involved in Antibody‐Dependent Enhancement of Dengue Virus Infection in Humans

Jacky Flipse Jan Wilschut Jolanda M. Smit

Traffic Vol. 14 No. 1 pp. 25-35 · Wiley

View at Publisher Save 10.1111/tra.12012

Abstract

Dengue is the most common arthropod‐borne viral infection in humans with ∼50 million cases annually worldwide. In recent decades, a steady increase in the number of severe dengue cases has been seen. Severe dengue disease is most often observed in individuals that have pre‐existing immunity against heterotypic dengue subtypes and in infants with low levels of maternal dengue antibodies. The generally accepted hypothesis explaining the immunopathogenesis of severe dengue is called antibody‐dependent enhancement of dengue infection. Here, circulating antibodies bind to the newly infecting virus but do not neutralize infection. Rather, these antibodies increase the infected cell mass and virus production. Additionally, antiviral responses are diminished allowing massive virus particle production early in infection. The large infected cell mass and the high viral load are prelude for severe disease development. In this review, we discuss what is known about the trafficking of dengue virus in its human host cells, and the signalling pathways activated after virus detection, both in the absence and presence of antibodies against the virus. This review summarizes work that aims to better understand the complex immunopathogenesis of severe dengue disease.

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Details

Published: Oct 22, 2012
Vol/Issue: 14(1)
Pages: 25-35
License: View

Authors

J

Jacky Flipse

Department of Medical Microbiology, Molecular Virology Section University Medical Center Groningen, University of Groningen Groningen The Netherlands

J

Jan Wilschut

Department of Medical Microbiology, Molecular Virology Section University Medical Center Groningen, University of Groningen Groningen The Netherlands

J

Jolanda M. Smit

Department of Medical Microbiology, Molecular Virology Section University Medical Center Groningen, University of Groningen Groningen The Netherlands

Cite This Article

Jacky Flipse, Jan Wilschut, Jolanda M. Smit (2012). Molecular Mechanisms Involved in Antibody‐Dependent Enhancement of Dengue Virus Infection in Humans. Traffic, 14(1), 25-35. https://doi.org/10.1111/tra.12012

Molecular Mechanisms Involved in Antibody‐Dependent Enhancement of Dengue Virus Infection in Humans

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