Protein transport in growing and steady‐state cilia

Karl F. Lechtreck; Julie C. Van De Weghe; James Aaron Harris; Peiwei Liu

doi:10.1111/tra.12474

journal article Mar 29, 2017

Protein transport in growing and steady‐state cilia

Karl F. Lechtreck Julie C. Van De Weghe James Aaron Harris Peiwei Liu

Traffic Vol. 18 No. 5 pp. 277-286 · Wiley

View at Publisher Save 10.1111/tra.12474

Abstract

Cilia and eukaryotic flagella are threadlike cell extensions with motile and sensory functions. Their assembly requires intraflagellar transport (IFT), a bidirectional motor‐driven transport of protein carriers along the axonemal microtubules. IFT moves ample amounts of structural proteins including tubulin into growing cilia likely explaining its critical role for assembly. IFT continues in non‐growing cilia contributing to a variety of processes ranging from axonemal maintenance and the export of non‐ciliary proteins to cell locomotion and ciliary signaling. Here, we discuss recent data on cues regulating the type, amount and timing of cargo transported by IFT. A regulation of IFT‐cargo interactions is critical to establish, maintain and adjust ciliary length, protein composition and function.

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Details

Published: Mar 29, 2017
Vol/Issue: 18(5)
Pages: 277-286
License: View

Authors

K

Karl F. Lechtreck

Department of Cellular Biology University of Georgia Athens Georgia

J

Julie C. Van De Weghe

Department of Cellular Biology University of Georgia Athens Georgia

J

James Aaron Harris

Department of Cellular Biology University of Georgia Athens Georgia

P

Peiwei Liu

Department of Cellular Biology University of Georgia Athens Georgia

Funding

National Institutes of Health Award: R01GM110413

National Institute of General Medical Sciences

Cite This Article

Karl F. Lechtreck, Julie C. Van De Weghe, James Aaron Harris, et al. (2017). Protein transport in growing and steady‐state cilia. Traffic, 18(5), 277-286. https://doi.org/10.1111/tra.12474

Protein transport in growing and steady‐state cilia

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