Exosomes: Revisiting their role as “garbage bags”

Michel Vidal

doi:10.1111/tra.12687

journal article Oct 01, 2019

Exosomes: Revisiting their role as “garbage bags”

Michel Vidal

Traffic Vol. 20 No. 11 pp. 815-828 · Wiley

View at Publisher Save 10.1111/tra.12687

Abstract

AbstractIn recent years, the term “extracellular vesicle” (EV) has been used to define different types of vesicles released by various cells. It includes plasma membrane‐derived vesicles (ectosomes/microvesicles) and endosome‐derived vesicles (exosomes). Although it remains difficult to evaluate the compartment of origin of the two kinds of vesicles once released, it is critical to discriminate these vesicles because their mode of biogenesis is probably directly related to their physiologic function and/or to the physio‐pathologic state of the producing cell. The purpose of this review is to specifically consider exosome secretion and its consequences in terms of a material loss for producing cells, rather than on the effects of exosomes once they are taken up by recipient cells. I especially describe one putative basic function of exosomes, that is, to convey material out of cells for off‐site degradation by recipient cells. As illustrated by some examples, these components could be evacuated from cells for various reasons, for example, to promote “differentiation” or enhance homeostatic responses. This basic function might explain why so many diseases have made use of the exosomal pathway during pathogenesis.

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Metrics

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Citations

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References

Details

Published: Oct 01, 2019
Vol/Issue: 20(11)
Pages: 815-828
License: View

Authors

M

Michel Vidal

LPHI – Université de Montpellier, CNRS Montpellier France

Cite This Article

Michel Vidal (2019). Exosomes: Revisiting their role as “garbage bags”. Traffic, 20(11), 815-828. https://doi.org/10.1111/tra.12687

Exosomes: Revisiting their role as “garbage bags”

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