Incidence of anti‐D alloimmunization in D‐negative individuals receiving D‐positive red blood cell transfusion: A systematic review and meta‐analysis

YanLi Ji; Guangping Luo; Yongshui Fu

doi:10.1111/vox.13232

journal article Jan 10, 2022

Incidence of anti‐D alloimmunization in D‐negative individuals receiving D‐positive red blood cell transfusion: A systematic review and meta‐analysis

YanLi Ji

Guangping Luo Yongshui Fu

Vox Sanguinis Vol. 117 No. 5 pp. 633-640 · Wiley

View at Publisher Save 10.1111/vox.13232

Abstract

AbstractBackground and ObjectivesThe transfusion of D‐negative red blood cells (RBCs) to D‐negative patients has been widely adopted to prevent anti‐D alloimmunization, especially in women of childbearing age. Still, transfusion of D‐positive RBCs to D‐negative recipients is occasionally inevitable in practice, and the resulting incidence of anti‐D in different D‐negative groups of patients has not been well summarized.Materials and MethodsWe searched the relevant literature using PubMed, Cochrane Library, and Embase databases from inception date to 30 September 2021. We looked for studies of anti‐D occurring in D‐negative recipients who received D‐positive RBC transfusions. The anti‐D incidence was summarized with 95% confidence intervals (CIs). Data with similar characteristics were combined using a random‐effects model.ResultsAbout 42 studies (2226 cases), which found anti‐D, the exact volume of D‐positive RBC transfused, and the follow‐up time for anti‐D detection, met the inclusion criteria. The pooled anti‐D incidence was 64% (95% CI, range 55%–74%) in volunteers receiving small volumes of D‐positive RBCs, 84% (95% CI, 74%–94%) in those receiving whole units, 26% (95% CI, 19%–32%) in mixed patients, 12% (95% CI, 8%–16%) in oncology patients, 27% (95% CI, 13%–40%) in trauma patients, 4% (95% CI, 0%–8%) in immune‐compromised transplant patients, and 6% (95% CI, 1%–39%) in those with AIDS.ConclusionCompared with the high frequency of anti‐D in healthy D‐negative volunteers given D‐positive RBCs, we found a lower rate of anti‐D immunization in various D‐negative patients and almost none in transplant and AIDS patients.

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Citations

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Details

Published: Jan 10, 2022
Vol/Issue: 117(5)
Pages: 633-640
License: View

Authors

Y

YanLi Ji

Institute of Clinical Blood Transfusion Guangzhou Blood Center Guangzhou People's Republic of China

G

Guangping Luo

Institute of Clinical Blood Transfusion Guangzhou Blood Center Guangzhou People's Republic of China

Y

Yongshui Fu

Institute of Clinical Blood Transfusion Guangzhou Blood Center Guangzhou People's Republic of China

Funding

National Natural Science Foundation of China Award: 82070198

Cite This Article

YanLi Ji, Guangping Luo, Yongshui Fu (2022). Incidence of anti‐D alloimmunization in D‐negative individuals receiving D‐positive red blood cell transfusion: A systematic review and meta‐analysis. Vox Sanguinis, 117(5), 633-640. https://doi.org/10.1111/vox.13232

Incidence of anti‐D alloimmunization in D‐negative individuals receiving D‐positive red blood cell transfusion: A systematic review and meta‐analysis

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