Insights into pathophysiology and therapeutic strategies for heat stroke: Lessons from a baboon model

Mashan Abdullah; Salleh Ehaideb; George Roberts; Abderrezak Bouchama

doi:10.1113/ep091586

journal article Open Access Dec 20, 2023

Insights into pathophysiology and therapeutic strategies for heat stroke: Lessons from a baboon model

Mashan Abdullah Salleh Ehaideb George Roberts Abderrezak Bouchama

Experimental Physiology Vol. 109 No. 4 pp. 484-501 · Wiley

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Abstract

AbstractHeat stroke is a perilous condition marked by severe hyperthermia and extensive multiorgan dysfunction, posing a considerable risk of mortality if not promptly identified and treated. Furthermore, the complex biological mechanisms underlying heat stroke‐induced tissue and cell damage across organ systems remain incompletely understood. This knowledge gap has hindered the advancement of effective preventive and therapeutic strategies against this condition. In this narrative review, we synthesize key insights gained over a decade using a translational baboon model of heat stroke. By replicating heat stroke pathology in a non‐human primate species that closely resembles humans, we have unveiled novel insights into the pathways of organ injury and cell death elicited by this condition. Here, we contextualize and integrate the lessons learned concerning heat stroke pathophysiology and recovery, areas that are inherently challenging to investigate directly in human subjects. We suggest novel research directions to advance the understanding of the complex mechanisms underlying cell death and organ injury. This may lead to precise therapeutic strategies that benefit individuals suffering from this debilitating condition.

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Details

Published: Dec 20, 2023
Vol/Issue: 109(4)
Pages: 484-501
License: View

Authors

M

Mashan Abdullah

Experimental Medicine Department, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard Health Affairs Riyadh Saudi Arabia

S

Salleh Ehaideb

Experimental Medicine Department, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard Health Affairs Riyadh Saudi Arabia

G

George Roberts

Pathology and Laboratory Medicine King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia

A

Abderrezak Bouchama

Experimental Medicine Department, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City Ministry of National Guard Health Affairs Riyadh Saudi Arabia

Cite This Article

Mashan Abdullah, Salleh Ehaideb, George Roberts, et al. (2023). Insights into pathophysiology and therapeutic strategies for heat stroke: Lessons from a baboon model. Experimental Physiology, 109(4), 484-501. https://doi.org/10.1113/ep091586

Insights into pathophysiology and therapeutic strategies for heat stroke: Lessons from a baboon model

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