Cellular electrophysiological principles that modulate secretion from synovial fibroblasts

R. B. Clark; T. A. Schmidt; F. B. Sachse; D. Boyle; G. S. Firestein; W. R. Giles

doi:10.1113/jp270209

journal article Jan 05, 2017

Cellular electrophysiological principles that modulate secretion from synovial fibroblasts

R. B. Clark T. A. Schmidt F. B. Sachse D. Boyle G. S. Firestein W. R. Giles

The Journal of Physiology Vol. 595 No. 3 pp. 635-645 · Wiley

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Abstract

AbstractRheumatoid arthritis (RA) is a progressive disease that affects both pediatric and adult populations. The cellular basis for RA has been investigated extensively using animal models, human tissues and isolated cells in culture. However, many aspects of its aetiology and molecular mechanisms remain unknown. Some of the electrophysiological principles that regulate secretion of essential lubricants (hyaluronan and lubricin) and cytokines from synovial fibroblasts have been identified. Data sets describing the main types of ion channels that are expressed in human synovial fibroblast preparations have begun to provide important new insights into the interplay among: (i) ion fluxes, (ii) Ca2+ release from the endoplasmic reticulum, (iii) intercellular coupling, and (iv) both transient and longer duration changes in synovial fibroblast membrane potential. A combination of this information, knowledge of similar patterns of responses in cells that regulate the immune system, and the availability of adult human synovial fibroblasts are likely to provide new pathophysiological insights.

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Details

Published: Jan 05, 2017
Vol/Issue: 595(3)
Pages: 635-645
License: View

Authors

R

R. B. Clark

Faculties of Kinesiology and Medicine University of Calgary Calgary Canada T2N 1N4

T

T. A. Schmidt

Faculties of Kinesiology and Engineering University of Calgary Calgary Canada T2N 1N4

F

F. B. Sachse

Department of Bioengineering and Nora Eccles Harrison Cardiovascular Research and Training Institute University of Utah Salt Lake City UT USA

D

D. Boyle

Department of Medicine University of California San Diego CA USA

G

G. S. Firestein

Department of Medicine University of California San Diego CA USA

W

W. R. Giles

Faculties of Kinesiology and Medicine University of Calgary Calgary Canada T2N 1N4

Funding

Canada Foundation for Innovation

Natural Sciences and Engineering Research Council of Canada

Canadian Institutes of Health Research

Alberta Heritage Foundation for Medical Research

Cite This Article

R. B. Clark, T. A. Schmidt, F. B. Sachse, et al. (2017). Cellular electrophysiological principles that modulate secretion from synovial fibroblasts. The Journal of Physiology, 595(3), 635-645. https://doi.org/10.1113/jp270209

Cellular electrophysiological principles that modulate secretion from synovial fibroblasts

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