Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour

Patricia Bonnavion; Laura E. Mickelsen; Akie Fujita; Luis de Lecea; Alexander C. Jackson

doi:10.1113/jp271946

journal article Jul 19, 2016

Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour

Patricia Bonnavion Laura E. Mickelsen Akie Fujita Luis de Lecea

Alexander C. Jackson

The Journal of Physiology Vol. 594 No. 22 pp. 6443-6462 · Wiley

View at Publisher Save 10.1113/jp271946

Abstract

AbstractThe hypothalamus is among the most phylogenetically conserved regions in the vertebrate brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By integrating signals arising from both the brain and periphery, it governs a litany of behaviourally important functions essential for survival. In particular, the lateral hypothalamic area (LHA) is central to the orchestration of sleep–wake states, feeding, energy balance and motivated behaviour. Underlying these diverse functions is a heterogeneous assembly of cell populations typically defined by neurochemical markers, such as the well‐described neuropeptides hypocretin/orexin and melanin‐concentrating hormone. However, anatomical and functional evidence suggests a rich diversity of other cell populations with complex neurochemical profiles that include neuropeptides, receptors and components of fast neurotransmission. Collectively, the LHA acts as a hub for the integration of diverse central and peripheral signals and, through complex local and long‐range output circuits, coordinates adaptive behavioural responses to the environment. Despite tremendous progress in our understanding of the LHA, defining the identity of functionally discrete LHA cell types, and their roles in driving complex behaviour, remain significant challenges in the field. In this review, we discuss advances in our understanding of the neurochemical and cellular heterogeneity of LHA neurons and the recent application of powerful new techniques, such as opto‐ and chemogenetics, in defining the role of LHA circuits in feeding, reward, arousal and stress. From pioneering work to recent developments, we review how the interrogation of LHA cells and circuits is contributing to a mechanistic understanding of how the LHA coordinates complex behaviour.
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Details

Published: Jul 19, 2016
Vol/Issue: 594(22)
Pages: 6443-6462
License: View

Authors

P

Patricia Bonnavion

Laboratory of Neurophysiology Université Libre de Bruxelles (ULB)‐UNI 1050 Brussels Belgium

L

Laura E. Mickelsen

Department of Physiology and Neurobiology University of Connecticut Storrs CT 06269 USA

A

Akie Fujita

Department of Physiology and Neurobiology University of Connecticut Storrs CT 06269 USA

L

Luis de Lecea

Department of Psychiatry and Behavioural Sciences Stanford University School of Medicine Stanford CA 94305 USA

A

Alexander C. Jackson

Department of Physiology and Neurobiology University of Connecticut Storrs CT 06269 USA

Funding

National Institute of Mental Health Award: R01MH087592061

National Institute on Aging Award: R01AG04767102

National Alliance for Research on Schizophrenia and Depression

Hilda and Preston Davis Foundation

Klarman Family Foundation

Cite This Article

Patricia Bonnavion, Laura E. Mickelsen, Akie Fujita, et al. (2016). Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour. The Journal of Physiology, 594(22), 6443-6462. https://doi.org/10.1113/jp271946

Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour

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