BishtRef
Articles Journals Publishers Authors Subjects Most Cited New Papers Year Stats Open Access
journal article Oct 12, 2020

Effects of e‐cigarettes and vaping devices on cardiac and pulmonary physiology

MuChun Tsai ORCID Min Kwang Byun ORCID John Shin Laura E. Crotty Alexander ORCID
The Journal of Physiology Vol. 598 No. 22 pp. 5039-5062 · Wiley
View at Publisher Save 10.1113/jp279754
Abstract
AbstractE‐cigarette aerosols are exceedingly different from conventional tobacco smoke, containing dozens of chemicals not found in cigarette smoke. It is highly likely that chronic use of e‐cigarettes will induce pathological changes in both the heart and lungs. Here we review human and animal studies published to date and summarize the cardiopulmonary physiological changes caused by vaping. In terms of cardiac physiology, acute exposure to e‐cigarette aerosols in human subjects led to increased blood pressure and heart rate, similar to traditional cigarettes. Chronic exposure to e‐cigarette aerosols using animal models caused increased arterial stiffness, vascular endothelial changes, increased angiogenesis, cardiorenal fibrosis and increased atherosclerotic plaque formation. Pulmonary physiology is also affected by e‐cigarette aerosol inhalation, with increased airway reactivity, airway obstruction, inflammation and emphysema. Research thus far demonstrates that the heart and lung undergo numerous changes in response to e‐cigarette use, and disease development will depend on how those changes combine with both environmental and genetic factors. E‐cigarettes have been advertised as a healthy alternative to cigarette smoking, and users are under the impression that vaping of e‐cigarettes is harmless, but these claims that e‐cigarettes are safer and healthier are not based on evidence. Data from both humans and animal models are consistent in demonstrating that vaping of e‐cigarettes causes health effects both similar to and disparate from those of cigarette smoking. Further work is needed to define the long‐term cardiopulmonary effects of e‐cigarette use in humans.
image
Topics

No keywords indexed for this article. Browse by subject →

References
69
[4]
Bero LA "The limits of competing interest disclosures" Tob Control (2005)
[18]
National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems (2018)
[21]
Fetterman JL "Alterations in vascular function associated with the use of combustible and electronic cigarettes" J Am Heart Assoc (2020) 10.1161/jaha.119.014570
[23]
Fogt DL "Effects of acute vaporized nicotine in non‐tobacco users at rest and during exercise" Int J Exerc Sci (2016)
[31]
Hawk ET "E‐cigarettes: unstandardized, under‐regulated, understudied, and unknown health and cancer risks" Cancer Res (2019) 10.1158/0008-5472.can-19-2997
[45]
Adverse Effects of Cigarette and Noncigarette Smoke Exposure on the Autonomic Nervous System

Holly R. Middlekauff, Jeanie Park, Roya S. Moheimani

Journal of the American College of Cardiology 10.1016/j.jacc.2014.06.1201

Showing 50 of 69 references

Cited By
150
Impact of e-cigarette vaping on the immune system across the body

Jorge A. Masso-Silva, Alexia Perryman · 2026

Physiological Reviews
Metrics
150
Citations
69
References
Details
Published
Oct 12, 2020
Vol/Issue
598(22)
Pages
5039-5062
License
View
Authors
M
MuChun Tsai

Division of Pulmonary Critical Care and Sleep Medicine Department of Internal Medicine The Ohio State University Columbus OH USA

M
Min Kwang Byun

Pulmonary and Critical Care Section VA San Diego Healthcare System La Jolla CA USA; Division of Pulmonary Critical Care and Sleep Medicine Department of Medicine University of California San Diego (UCSD) La Jolla CA USA; Division of Pulmonology Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine Seoul South Korea

J
John Shin

Pulmonary and Critical Care Section VA San Diego Healthcare System La Jolla CA USA; Division of Pulmonary Critical Care and Sleep Medicine Department of Medicine University of California San Diego (UCSD) La Jolla CA USA

L
Laura E. Crotty Alexander

Pulmonary and Critical Care Section VA San Diego Healthcare System La Jolla CA USA; Division of Pulmonary Critical Care and Sleep Medicine Department of Medicine University of California San Diego (UCSD) La Jolla CA USA

Cite This Article
MuChun Tsai, Min Kwang Byun, John Shin, et al. (2020). Effects of e‐cigarettes and vaping devices on cardiac and pulmonary physiology. The Journal of Physiology, 598(22), 5039-5062. https://doi.org/10.1113/jp279754
Related

You May Also Like

A quantitative description of membrane current and its application to conduction and excitation in nerve

A. L. Hodgkin, A. F. Huxley · 1952

22,993 citations

Receptive fields, binocular interaction and functional architecture in the cat's visual cortex

D. H. Hubel, T. N. Wiesel · 1962

13,742 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

T. V. P. Bliss, T. Lømo · 1973

5,146 citations

Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation

M. A. Nitsche, W. Paulus · 2000

4,683 citations

New methods for calculating metabolic rate with special reference to protein metabolism

J. B. de V. Weir · 1949

4,142 citations