Role of AMPA receptor desensitization in short term depression – lessons from retinogeniculate synapses

Jakob von Engelhardt

doi:10.1113/jp280878

journal article Open Access Jul 26, 2021

Role of AMPA receptor desensitization in short term depression – lessons from retinogeniculate synapses

Jakob von Engelhardt

The Journal of Physiology Vol. 600 No. 2 pp. 201-215 · Wiley

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Abstract

AbstractRepetitive synapse activity induces various forms of short‐term plasticity. The role of presynaptic mechanisms such as residual Ca2+ and vesicle depletion in short‐term facilitation and short‐term depression is well established. On the other hand, the contribution of postsynaptic mechanisms such as receptor desensitization and saturation to short‐term plasticity is less well known and often ignored. In this review, I will describe short‐term plasticity in retinogeniculate synapses of relay neurons of the dorsal lateral geniculate nucleus (dLGN) to exemplify the synaptic properties that facilitate the contribution of AMPA receptor desensitization to short‐term plasticity. These include high vesicle release probability, glutamate spillover and, importantly, slow recovery from desensitization of AMPA receptors. The latter is strongly regulated by the interaction of AMPA receptors with auxiliary proteins such as CKAMP44. Finally, I discuss the relevance of short‐term plasticity in retinogeniculate synapses for the processing of visual information by LGN relay neurons.
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Published: Jul 26, 2021
Vol/Issue: 600(2)
Pages: 201-215
License: View

Authors

J

Jakob von Engelhardt

Institute of Pathophysiology Focus Program Translational Neuroscience (FTN) University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany

Cite This Article

Jakob von Engelhardt (2021). Role of AMPA receptor desensitization in short term depression – lessons from retinogeniculate synapses. The Journal of Physiology, 600(2), 201-215. https://doi.org/10.1113/jp280878

Role of AMPA receptor desensitization in short term depression – lessons from retinogeniculate synapses

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