Hepatic stellate cells in physiology and pathology

Dakota R. Kamm; Kyle S. McCommis

doi:10.1113/jp281061

journal article Mar 30, 2022

Hepatic stellate cells in physiology and pathology

Dakota R. Kamm Kyle S. McCommis

The Journal of Physiology Vol. 600 No. 8 pp. 1825-1837 · Wiley

View at Publisher Save 10.1113/jp281061

Abstract

AbstractHepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve numerous critical functions in the normal liver and in response to injury. HSCs are primarily known for their activation upon liver injury and for producing the collagen‐rich extracellular matrix in liver fibrosis. In the absence of liver injury, HSCs reside in a quiescent state, in which their main function appears to be the storage of retinoids or vitamin A‐containing metabolites. Less appreciated functions of HSCs include amplifying the hepatic inflammatory response and expressing growth factors that are critical for liver development and both the initiation and termination of liver regeneration. Recent single‐cell RNA sequencing studies have corroborated earlier studies indictaing that HSC activation involves a diverse array of phenotypic alterations and identified unique HSC populations. This review serves to highlight these many functions of HSCs, and to briefly describe the recent genetic tools that will help to thoroughly investigate the role of HSCs in hepatic physiology and pathology.
image

Topics

No keywords indexed for this article. Browse by subject →

References

98

[1]

10.1002/hep4.1854

[2]

10.1002/hep.22721

[3]

10.1002/hep.24119

[4]

10.1016/j.jhep.2003.10.012

[5]

10.1002/hep.1840190224

[6]

10.1172/jci24282

[7]

10.1074/jbc.m312410200

[8]

10.1172/jci118055

[9]

10.1083/jcb.132.6.1133

[10]

10.1111/j.1365-2036.2011.04912.x

[11]

10.1016/j.cgh.2017.12.001

[12]

10.1152/ajpgi.00537.2004

[13]

10.1016/j.nut.2014.10.016

[14]

10.1053/j.gastro.2012.07.115

[15]

10.1172/jci114943

[16]

10.1111/hepr.13585

[17]

10.1016/s0002-9440(10)62476-5

[18]

10.1038/nm.2490

[19]

10.1074/jbc.275.4.2247

[20]

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

Scott L. Friedman

Physiological Reviews 10.1152/physrev.00013.2007

[21]

10.1073/pnas.82.24.8681

[22]

10.1016/s0945-053x(03)00017-9

[23]

10.1159/000198640

[24]

10.1038/labinvest.2012.54

[25]

10.1016/j.bbalip.2020.158674

[26]

Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD

Hannes Hagström, Patrik Nasr, Mattias Ekstedt et al.

Journal of Hepatology 10.1016/j.jhep.2017.07.027

[27]

10.1016/0014-4827(85)90243-5

[28]

10.1053/j.gastro.2011.12.044

[29]

10.1172/jci1018

[30]

10.1053/jhep.2003.50005

[31]

10.1053/j.gastro.2003.08.029

[32]

10.1073/pnas.73.10.3719

[33]

Molecular and cellular mechanisms of liver fibrosis and its regression

Tatiana Kisseleva, David Brenner

Nature Reviews Gastroenterology & Hepatology 10.1038/s41575-020-00372-7

[34]

10.1073/pnas.1201840109

[35]

10.1002/hep4.1628

[36]

10.1016/0014-4827(82)90283-x

[37]

10.1016/j.bbrc.2006.11.029

[38]

10.1007/bf02933897

[39]

10.1016/j.jhep.2016.11.011

[40]

10.1053/j.gastro.2020.01.027

[41]

10.1038/s41467-018-06318-7

[42]

10.1002/hep.20427

[43]

10.4103/1319-3767.37794

[44]

Martinez‐Hernandez A. "The hepatic extracellular matrix. I. Electron immunohistochemical studies in normal rat liver" Laboratory Investigation (1984)

[45]

Martinez‐Hernandez A. "The hepatic extracellular matrix. II. Electron immunohistochemical studies in rats with CCl4‐induced cirrhosis" Laboratory Investigation (1985)

[46]

10.15252/msb.20209682

[47]

10.1016/s0021-9258(18)88553-2

[48]

10.1002/hep.29025

[49]

McGee J. O. "The role of perisinusoidal cells in experimental hepatic fibrogenesis" Journal of Pathology (1972)

[50]

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Ingmar Mederacke, Christine C. Hsu, Juliane S. Troeger et al.

Nature Communications 10.1038/ncomms3823

Showing 50 of 98 references

Cited By

260

Decoupling multicellular activation circuits: MPDA-mediated co-delivery of quercetin/simvastatin for potent hepatic fibrosis reversal

Lu Zhang, Huan Shen · 2026

Chemical Engineering Journal

Supramolecular carrier-free biological nanofibers for treatment of liver fibrosis

Chen Jiang, Bowen Li · 2026

Colloids and Surfaces A: Physicoche...

Deacetylasperulosidic acid methyl ester attenuates liver fibrosis by modulating the SCFAs-Wnt/β-catenin signaling axis

Ting Jiang, Lingli Zheng · 2026

European Journal of Pharmacology

Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics

Xiao Ma, Tengda Huang · 2025

Signal Transduction and Targeted Th...

Development of a complex 3D in vitro alternative model to evaluate the safety of advanced materials

Melissa Anne Tutty, Tecla Simone · 2025

Toxicology and Applied Pharmacology

Hepatic Stellate Cells Functional Heterogeneity in Liver Cancer

Laura Sererols-Viñas, Gemma Garcia-Vicién · 2025

Seminars in Liver Disease

Empagliflozin reduces liver fibrosis by restoring catechol-O-methyltransferase activity associated with magnesium levels

Yoshihiro Hayashi, Emi Kawakita · 2025

Scientific Reports

Taohong Siwu Decoction modulates glutathione metabolism to suppress hepatocyte ferroptosis and demonstrates anti-fibrotic effects in the liver

Zhun Xiao, Siqi Gao · 2025

Journal of Ethnopharmacology

In vitro liver models for toxicological research

Ichiro Fukunaga, Takanori Takebe · 2025

Drug Metabolism and Pharmacokinetic...

The transcription factor ZNF469 regulates collagen production in liver fibrosis

Sebastian Steinhauser, David Estoppey · 2025

JCI Insight

The Origin and Fate of Liver Myofibroblasts

Hyun Young Kim, Sadatsugu Sakane · 2024

Cellular and Molecular Gastroentero...

Human umbilical cord mesenchymal stem cells enhance liver regeneration and decrease collagen content in fibrosis mice after partial hepatectomy by activating Wnt/&beta;-catenin signaling

Xuewei Li, Jinghui Feng · 2024

Acta Biochimica et Biophysica Sinic...

The immunology of sickness metabolism

Felix M. Wensveen, Marko Šestan · 2024

Cellular & Molecular Immunology

Hydrogel-Based Strategies for Liver Tissue Engineering

Yu Zhang, Luofei Li · 2024

Chem & Bio Engineering

Oxidative Stress in Liver Pathophysiology and Disease

Abdolamir Allameh, Reyhaneh Niayesh-Mehr · 2023

Antioxidants

Metrics

260

Citations

98

References

Details

Published: Mar 30, 2022
Vol/Issue: 600(8)
Pages: 1825-1837
License: View

Authors

D

Dakota R. Kamm

Department of Biochemistry & Molecular Biology Saint Louis University School of Medicine St Louis MO USA

K

Kyle S. McCommis

Department of Biochemistry & Molecular Biology Saint Louis University School of Medicine St Louis MO USA

Funding

National Institutes of Health Award: R00 HL136658

Cite This Article

Dakota R. Kamm, Kyle S. McCommis (2022). Hepatic stellate cells in physiology and pathology. The Journal of Physiology, 600(8), 1825-1837. https://doi.org/10.1113/jp281061

Hepatic stellate cells in physiology and pathology

You May Also Like