Volume‐activated chloride currents associated with the multidrug resistance P‐glycoprotein.

C F Higgins

doi:10.1113/jphysiol.1995.sp020562

journal article Jan 01, 1995

Volume‐activated chloride currents associated with the multidrug resistance P‐glycoprotein.

C F Higgins

The Journal of Physiology Vol. 482 No. suppl pp. 31-36 · Wiley

View at Publisher Save 10.1113/jphysiol.1995.sp020562

Abstract

The ability to regulate volume is an important property of most, if not all cells. In epithelial cells, amongst others, cell volume‐activated chloride channels are central to this response. The molecular identities of these channels are not yet known. Expression of the human multidrug resistance P‐glycoprotein (P‐gp) has been associated with cell volume‐regulated chloride currents, although the nature of this association is the subject of debate. Recent data indicate that P‐gp acts by regulating the activation of an endogenous channel protein. In this review, evidence associating P‐gp with cell volume‐activated chloride currents, and the possible mechanisms by which this might be achieved, are discussed.

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Published: Jan 01, 1995
Vol/Issue: 482(suppl)
Pages: 31-36
License: View

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C F Higgins

Cite This Article

C F Higgins (1995). Volume‐activated chloride currents associated with the multidrug resistance P‐glycoprotein.. The Journal of Physiology, 482(suppl), 31-36. https://doi.org/10.1113/jphysiol.1995.sp020562

Volume‐activated chloride currents associated with the multidrug resistance P‐glycoprotein.

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