Lactate supports a metabolic-epigenetic link in macrophage polarization

J. Van den Bossche, J. Baardman, M. P. J. de Winther, metabolic characterization of polarized M1 and M2 bone marrow-derived macrophages using real-time extracellular flux analysis. J. Vis. Exp. 105, 53424 (2015).

[11]

Macrophage plasticity and polarization: in vivo veritas

Antonio Sica, Alberto Mantovani

Journal of Clinical Investigation 10.1172/jci59643

[12]

10.1172/jci124615

[13]

10.1038/nrclinonc.2016.217

[14]

10.1038/ni.1937

[15]

10.1016/j.immuni.2015.02.005

[16]

The Metabolic Signature of Macrophage Responses

Antonella Viola, Fabio Munari, Ricardo Sánchez-Rodríguez et al.

Frontiers in Immunology 10.3389/fimmu.2019.01462

[17]

10.1002/jlb.3ru1218-496r

[18]

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

A MANTOVANI, S SOZZANI, M LOCATI et al.

Trends in Immunology 10.1016/s1471-4906(02)02302-5

[19]

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

Peter J. Murray, Judith E. Allen, Subhra K. Biswas et al.

Immunity 10.1016/j.immuni.2014.06.008

[20]

10.1126/science.1164097

[21]

10.1126/science.1218099

[22]

10.1016/j.cmet.2015.05.014

[23]

10.1016/j.bbrc.2013.09.037

[24]

10.1038/s41590-019-0453-7

[25]

10.7554/elife.11612

[26]

10.1038/s41467-020-20141-z

[27]

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

Karen G. de la Cruz-López, Leonardo Josué Castro-Muñoz, Diego O. Reyes-Hernández et al.

Frontiers in Oncology 10.3389/fonc.2019.01143

[28]

10.1038/s41416-019-0542-2

[29]

10.1126/science.1218530

[30]

10.1042/bj1480085

[31]

10.1073/pnas.1303360110

[32]

Cell-programmed nutrient partitioning in the tumour microenvironment

Bradley I. Reinfeld, Matthew Z. Madden, Melissa M. Wolf et al.

Nature 10.1038/s41586-021-03442-1

[33]

10.1016/j.cmet.2015.08.021

[34]

10.1038/cddis.2015.110

[35]

10.1038/ni.3796

[36]

10.1016/j.celrep.2016.09.069

[37]

10.1186/1471-2164-13-424

[38]

10.1016/j.nbt.2012.05.021

[39]

10.1038/nbt1026

[40]

10.1038/s41598-018-35679-8

[41]

10.1172/jci131335

[42]

10.1016/j.cmet.2018.08.012

[43]

10.1016/j.canlet.2019.12.010

[44]

10.1038/s41598-020-67079-2

[45]

10.1016/j.ejmech.2018.09.001

[46]

10.1016/j.cmet.2019.08.014

[47]

10.1074/jbc.ra119.011081

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Details

Published: Nov 12, 2021
Vol/Issue: 7(46)

Authors

J

Jordan T. Noe

Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, USA.; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.

B

Beatriz E. Rendon

J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.

A

Anne E. Geller

J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.

L

Lindsey R. Conroy

Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.

S

Samantha M. Morrissey

J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.

L

Lyndsay E.A. Young

Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA.

R

Ronald C. Bruntz

Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA.

E

Eun J. Kim

J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.

A

Ashley Wise-Mitchell

J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.

M

Mariana Barbosa de Souza Rizzo

J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.

E

Eric R. Relich

Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.

B

Becca V. Baby

J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.

L

Lance A. Johnson

Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40356, USA.

H

Hayley C. Affronti

Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

K

Kelly M. McMasters

J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Division of Immunotherapy, Department of Surgery, University of Louisville, Louisville, KY 40202, USA.

B

Brian F. Clem

Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, USA.; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.

M

Matthew S. Gentry

Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA.

J

Jun Yan

J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.; Division of Immunotherapy, Department of Surgery, University of Louisville, Louisville, KY 40202, USA.

K

Kathryn E. Wellen

Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

R

Ramon C. Sun

Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40356, USA.

R

Robert A. Mitchell

Department of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, USA.; J.G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.; Department of Microbiology and Immunology, University of Louisville, Louisville, KY 40202, USA.; Division of Immunotherapy, Department of Surgery, University of Louisville, Louisville, KY 40202, USA.

Cite This Article

Jordan T. Noe, Beatriz E. Rendon, Anne E. Geller, et al. (2021). Lactate supports a metabolic-epigenetic link in macrophage polarization. Science Advances, 7(46). https://doi.org/10.1126/sciadv.abi8602

Lactate supports a metabolic-epigenetic link in macrophage polarization

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