Distinct manifold encoding of navigational information in the subiculum and hippocampus

Shinya Nakai; Takuma Kitanishi; Kenji Mizuseki

doi:10.1126/sciadv.adi4471

journal article Feb 02, 2024

Distinct manifold encoding of navigational information in the subiculum and hippocampus

Shinya Nakai

Takuma Kitanishi

Kenji Mizuseki

Science Advances Vol. 10 No. 5 · American Association for the Advancement of Science (AAAS)

View at Publisher Save 10.1126/sciadv.adi4471

Abstract

The subiculum (SUB) plays a crucial role in spatial navigation and encodes navigational information differently from the hippocampal CA1 area. However, the representation of subicular population activity remains unknown. Here, we investigated the neuronal population activity recorded extracellularly from the CA1 and SUB of rats performing T-maze and open-field tasks. The trajectory of population activity in both areas was confined to low-dimensional neural manifolds homoeomorphic to external space. The manifolds conveyed position, speed, and future path information with higher decoding accuracy in the SUB than in the CA1. The manifolds exhibited common geometry across rats and regions for the CA1 and SUB and between tasks in the SUB. During post-task ripples in slow-wave sleep, population activity represented reward locations/events more frequently in the SUB than in CA1. Thus, the CA1 and SUB encode information distinctly into the neural manifolds that underlie navigational information processing during wakefulness and sleep.

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References

Details

Published: Feb 02, 2024
Vol/Issue: 10(5)

Authors

S

Shinya Nakai

Department of Physiology, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan.; Department of Physiology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.

T

Takuma Kitanishi

Department of Physiology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo 153-8902, Japan.; Komaba Institute for Science, The University of Tokyo, Meguro, Tokyo 153-8902, Japan.; PRESTO, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan.

K

Kenji Mizuseki

Department of Physiology, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan.; Department of Physiology, Graduate School of Medicine, Osaka City University, Osaka 545-8585, Japan.

Cite This Article

Shinya Nakai, Takuma Kitanishi, Kenji Mizuseki (2024). Distinct manifold encoding of navigational information in the subiculum and hippocampus. Science Advances, 10(5). https://doi.org/10.1126/sciadv.adi4471

Distinct manifold encoding of navigational information in the subiculum and hippocampus

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