Creating a False Memory in the Hippocampus

Steve Ramirez; Xingguo Liu; Pei-Ann Lin; Junghyup Suh; Michele Pignatelli; Roger L. Redondo; Tomás J. Ryan; Susumu Tonegawa

doi:10.1126/science.1239073

journal article Jul 26, 2013

Creating a False Memory in the Hippocampus

Steve Ramirez Xingguo Liu

Pei-Ann Lin Junghyup Suh Michele Pignatelli

Roger L. Redondo Tomás J. Ryan Susumu Tonegawa

Science Vol. 341 No. 6144 pp. 387-391 · American Association for the Advancement of Science (AAAS)

View at Publisher Save 10.1126/science.1239073

Abstract

Can You Trust Your Memory?

Being highly imaginative animals, humans constantly recall past experiences. These internally generated stimuli sometimes get associated with concurrent external stimuli, which can lead to the formation of false memories.

Ramirez
et al.

(p.
387
; see the cover) identified a population of cells in the dentate gyrus of the mouse hippocampus that encoded a particular context and were able to generate a false memory and study its neural and behavioral interactions with true memories. Optogenetic reactivation of memory engram–bearing cells was not only sufficient for the behavioral recall of that memory, but could also serve as a conditioned stimulus for the formation of an associative memory.

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References

Details

Published: Jul 26, 2013
Vol/Issue: 341(6144)
Pages: 387-391

Authors

S

Steve Ramirez

RIKEN–Massachusetts Institute of Technology (MIT) Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.

X

Xingguo Liu

RIKEN–Massachusetts Institute of Technology (MIT) Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.

P

Pei-Ann Lin

RIKEN–Massachusetts Institute of Technology (MIT) Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.

J

Junghyup Suh

RIKEN–Massachusetts Institute of Technology (MIT) Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.

M

Michele Pignatelli

RIKEN–Massachusetts Institute of Technology (MIT) Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.

R

Roger L. Redondo

RIKEN–Massachusetts Institute of Technology (MIT) Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.

T

Tomás J. Ryan

RIKEN–Massachusetts Institute of Technology (MIT) Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.

S

Susumu Tonegawa

RIKEN–Massachusetts Institute of Technology (MIT) Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.

Cite This Article

Steve Ramirez, Xingguo Liu, Pei-Ann Lin, et al. (2013). Creating a False Memory in the Hippocampus. Science, 341(6144), 387-391. https://doi.org/10.1126/science.1239073

Creating a False Memory in the Hippocampus

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