journal article Aug 17, 1979

Drug Discrimination Training with Progressively Lowered Doses

View at Publisher Save 10.1126/science.462182
Abstract
Rats were trained to discriminate drug from no-drug conditions in a two-lever operant task. Moderately high dosages were used initially. Whenever the discrimination was learned, training was continued with progressively reduced dosages. Eventually the rats discriminated extremely low doses of phenobarbital, chlordiazepoxide, cyclazocine, and fentanyl.
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References
12
[1]
BARRY, H, CLASSIFICATION OF DRUGS ACCORDING TO THEIR DISCRIMINABLE EFFECTS IN RATS, FEDERATION PROCEEDINGS 33: 1814 (1974).
[2]
BARRY, H, PROLONGED MEASUREMENTS OF DISCRIMINATION BETWEEN ALCOHOL AND NONDRUG STATES, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 65: 349 (1968). 10.1037/h0025556
[3]
BLISS, D.K., THEORETICAL EXPLANATIONS OF DRUG-DISSOCIATED BEHAVIORS, FEDERATION PROCEEDINGS 33: 1787 (1974).
[4]
COLPAERT F.C. COMMUNICATION.
[5]
CONGER, J.J., THE EFFECTS OF ALCOHOL ON CONFLICT BEHAVIOR IN THE ALBINO RAT, QUARTERLY JOURNAL OF STUDIES ON ALCOHOL 12: 1 (1951). 10.15288/qjsa.1951.12.001
[6]
GREENBERG, I, BEHAVIORALLY INDUCED SENSITIVITY TO DISCRIMINABLE PROPERTIES OF LSD, PSYCHOPHARMACOLOGIA 43: 229 (1975). 10.1007/bf00429255
[7]
HARRIS, R.T., STIMULUS PROPERTIES: 111 (1971).
[8]
KUBENA, R.K., 2 PROCEDURES FOR TRAINING DIFFERENTIAL RESPONSES IN ALCOHOL AND NONDURG CONDITIONS, JOURNAL OF PHARMACEUTICAL SCIENCES 58: 99 (1969). 10.1002/jps.2600580121
[9]
OVERTON, D.A., DRUG DISCRIMINATION: 283 (1978).
[10]
OVERTONE, D.A., STATE-DEPENDENT OR DISSOCIATED LEARNING PRODUCED WITH PENTOBARBITAL, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 57: 3 (1964). 10.1037/h0048023
[11]
Overton, D. A., Psychopharmacology 65: 291 (1979). 10.1007/bf00492218
[12]
Overton, D. A., Stimulus Properties of Drugs: 87 (1971).
Metrics
52
Citations
12
References
Details
Published
Aug 17, 1979
Vol/Issue
205(4407)
Pages
720-721
Cite This Article
Donald A. Overton (1979). Drug Discrimination Training with Progressively Lowered Doses. Science, 205(4407), 720-721. https://doi.org/10.1126/science.462182
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