Drug Discrimination Training with Progressively Lowered Doses

Donald A. Overton

doi:10.1126/science.462182

journal article Aug 17, 1979

Drug Discrimination Training with Progressively Lowered Doses

Donald A. Overton

Science Vol. 205 No. 4407 pp. 720-721 · American Association for the Advancement of Science (AAAS)

View at Publisher Save 10.1126/science.462182

Abstract

Rats were trained to discriminate drug from no-drug conditions in a two-lever operant task. Moderately high dosages were used initially. Whenever the discrimination was learned, training was continued with progressively reduced dosages. Eventually the rats discriminated extremely low doses of phenobarbital, chlordiazepoxide, cyclazocine, and fentanyl.

Topics

No keywords indexed for this article. Browse by subject →

References

12

[1]

BARRY, H, CLASSIFICATION OF DRUGS ACCORDING TO THEIR DISCRIMINABLE EFFECTS IN RATS, FEDERATION PROCEEDINGS 33: 1814 (1974).

[2]

BARRY, H, PROLONGED MEASUREMENTS OF DISCRIMINATION BETWEEN ALCOHOL AND NONDRUG STATES, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 65: 349 (1968). 10.1037/h0025556

[3]

BLISS, D.K., THEORETICAL EXPLANATIONS OF DRUG-DISSOCIATED BEHAVIORS, FEDERATION PROCEEDINGS 33: 1787 (1974).

[4]

COLPAERT F.C. COMMUNICATION.

[5]

CONGER, J.J., THE EFFECTS OF ALCOHOL ON CONFLICT BEHAVIOR IN THE ALBINO RAT, QUARTERLY JOURNAL OF STUDIES ON ALCOHOL 12: 1 (1951). 10.15288/qjsa.1951.12.001

[6]

GREENBERG, I, BEHAVIORALLY INDUCED SENSITIVITY TO DISCRIMINABLE PROPERTIES OF LSD, PSYCHOPHARMACOLOGIA 43: 229 (1975). 10.1007/bf00429255

[7]

HARRIS, R.T., STIMULUS PROPERTIES: 111 (1971).

[8]

KUBENA, R.K., 2 PROCEDURES FOR TRAINING DIFFERENTIAL RESPONSES IN ALCOHOL AND NONDURG CONDITIONS, JOURNAL OF PHARMACEUTICAL SCIENCES 58: 99 (1969). 10.1002/jps.2600580121

[9]

OVERTON, D.A., DRUG DISCRIMINATION: 283 (1978).

[10]

OVERTONE, D.A., STATE-DEPENDENT OR DISSOCIATED LEARNING PRODUCED WITH PENTOBARBITAL, JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY 57: 3 (1964). 10.1037/h0048023

[11]

Overton, D. A., Psychopharmacology 65: 291 (1979). 10.1007/bf00492218

[12]

Overton, D. A., Stimulus Properties of Drugs: 87 (1971).

Metrics

52

Citations

12

References

Details

Published: Aug 17, 1979
Vol/Issue: 205(4407)
Pages: 720-721

Authors

D

Donald A. Overton

Temple University School of Medicine, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129

Cite This Article

Donald A. Overton (1979). Drug Discrimination Training with Progressively Lowered Doses. Science, 205(4407), 720-721. https://doi.org/10.1126/science.462182

Drug Discrimination Training with Progressively Lowered Doses

You May Also Like