Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C

Zhejian Ji; Haishan Gao; Hongtao Yu

doi:10.1126/science.aaa4029

journal article Jun 12, 2015

Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C

Zhejian Ji Haishan Gao

Hongtao Yu

Science Vol. 348 No. 6240 pp. 1260-1264 · American Association for the Advancement of Science (AAAS)

View at Publisher Save 10.1126/science.aaa4029

Abstract

How cells sense connected chromosomes

Cells have a “checkpoint” that pauses cell division until all chromosomes are properly arranged on the mitotic spindle to allow precise distribution of one copy of each chromosome to each daughter cell. Hiruma
et al.
and Ji
et al.
explain the molecular mechanism by which cells sense that they are ready to divide. The protein kinase MPS1 associates with a protein complex at the kinetochore of the chromosome. Its activity produces signals that pause the cell cycle. When the chromosome becomes properly attached to the mitotic spindle, microtubules of the spindle physically compete for binding to the same site on the kinetochore where MPS1 is bound. Thus, once the kinetochore is properly attached, MPS1 dissociates, the inhibitory signal is lost, and cell division is allowed to proceed.

Science
, this issue pp.
1264
and
1260

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Metrics

199

Citations

35

References

Details

Published: Jun 12, 2015
Vol/Issue: 348(6240)
Pages: 1260-1264
License: View

Authors

Z

Zhejian Ji

Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 74390, USA.

H

Haishan Gao

Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 74390, USA.

H

Hongtao Yu

Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 74390, USA.

Funding

Welch Foundation Award: I-1441

Cancer Prevention and Research Institute of Texas Award: RP110465-P3

Cite This Article

Zhejian Ji, Haishan Gao, Hongtao Yu (2015). Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C. Science, 348(6240), 1260-1264. https://doi.org/10.1126/science.aaa4029

Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C

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