Macrophage compartmentalization in the brain and cerebrospinal fluid system

David A. D. Munro; Kiavash Movahedi; Josef Priller

doi:10.1126/sciimmunol.abk0391

journal article Mar 25, 2022

Macrophage compartmentalization in the brain and cerebrospinal fluid system

David A. D. Munro

Kiavash Movahedi

Josef Priller

Science Immunology Vol. 7 No. 69 · American Association for the Advancement of Science (AAAS)

View at Publisher Save 10.1126/sciimmunol.abk0391

Abstract

Macrophages reside within the diverse anatomical compartments of the central nervous system (CNS). Within each compartment, these phagocytes are exposed to unique combinations of niche signals and mechanical stimuli that instruct their tissue-specific identities. Whereas most CNS macrophages are tissue-embedded, the macrophages of the cerebrospinal fluid (CSF) system are bathed in an oscillating liquid. Studies using multiomics technologies have recently uncovered the transcriptomic and proteomic profiles of CSF macrophages, enhancing our understanding of their cellular characteristics in both rodents and humans. Here, we review the relationships between CNS macrophage populations, with a focus on the origins, phenotypes, and functions of CSF macrophages in health and disease.

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References

173

[1]

10.1038/s41593-019-0393-4

[2]

Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges

David Schafflick, Jolien Wolbert, Michael Heming et al.

Nature Neuroscience 10.1038/s41593-021-00880-y

[3]

10.1038/s41583-019-0201-x

[4]

10.1016/j.immuni.2018.02.014

[5]

10.1002/(sici)1097-0029(19980401)41:1<43::aid-jemt5>3.0.co;2-v

[6]

10.1172/jci.insight.121718

[7]

10.1212/nxi.0000000000000732

[8]

10.1242/dev.194449

[9]

10.1016/j.immuni.2019.02.007

[10]

Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling

Peter Wieghofer, Nora Hagemeyer, Roman Sankowski et al.

The EMBO Journal 10.15252/embj.2020105123

[11]

10.1126/science.aat7554

[12]

10.1038/ni.3423

[13]

10.1038/ni.3585

[14]

10.1073/pnas.1520398113

[15]

Junctions in the meninges and marginal glia

Sachio Nabeshima, T. S. Reese, Dennis M. D. Landis et al.

Journal of Comparative Neurology 10.1002/cne.901640202

[16]

10.1126/science.abf7844

[17]

10.1126/science.aau0964

[18]

10.1016/j.cell.2021.04.003

[19]

10.1126/sciimmunol.aav0492

[20]

10.1016/j.immuni.2020.02.015

[21]

10.1016/j.immuni.2019.08.017

[22]

10.1016/j.immuni.2020.06.008

[23]

10.1016/j.celrep.2021.108882

[24]

10.1016/0306-4522(90)90229-w

[25]

10.1016/j.immuni.2012.11.001

[26]

10.1038/nn.4222

[27]

10.1038/s41593-018-0290-2

[28]

10.1038/s41586-020-2777-8

[29]

10.1084/jem.20182037

[30]

10.1038/ni.2360

[31]

10.1016/j.cell.2014.11.018

[32]

10.1084/jem.20180247

[33]

10.1038/s41467-018-07295-7

[34]

10.1126/science.1194637

[35]

10.1093/brain/awt259

[36]

10.1084/jem.20091419

[37]

10.1016/j.cell.2019.08.053

[38]

H. Cushing, Studies on the cerebro-spinal fluid: I. Introduction. J. Med. Res. 31, 1–19 (1914).

[39]

10.1152/ajpcell.00041.2017

[40]

10.1186/2045-8118-8-5

[41]

10.1523/jneurosci.3246-14.2015

[42]

10.1126/science.1119133

[43]

10.1016/j.cub.2018.11.059

[44]

10.1126/scitranslmed.3003748

[45]

10.1038/s41467-018-07318-3

[46]

10.1016/0006-8993(85)91383-6

[47]

L. H. Weed, Studies on cerebro-spinal fluid. No. IV : The dual source of cerebro-spinal fluid. J. Med. Res. 31, 93–118.11 (1914).

[48]

10.1038/nature14432

[49]

10.1038/s41586-018-0368-8

[50]

10.1038/s41586-019-1419-5

Showing 50 of 173 references

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References

Details

Published: Mar 25, 2022
Vol/Issue: 7(69)

Authors

D

David A. D. Munro

UK Dementia Research Institute at University of Edinburgh, Edinburgh EH16 4TJ, UK.

K

Kiavash Movahedi

Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium.; Laboratory of Molecular and Cellular Therapy, Department of Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium.

J

Josef Priller

UK Dementia Research Institute at University of Edinburgh, Edinburgh EH16 4TJ, UK.; Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité–Universitätsmedizin Berlin and DZNE, 10117 Berlin, Germany.; Technical University of Munich, School of Medicine, Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, 81675 Munich, Germany.; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, 16 De Crespigny Park, London SE5 8AF, UK.

Cite This Article

David A. D. Munro, Kiavash Movahedi, Josef Priller (2022). Macrophage compartmentalization in the brain and cerebrospinal fluid system. Science Immunology, 7(69). https://doi.org/10.1126/sciimmunol.abk0391

Macrophage compartmentalization in the brain and cerebrospinal fluid system

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