CLOCK, SIRT1, and HDAC2 Knockdown along with Melatonin Intervention Significantly Decreased the Level Glucocorticoid Receptor

Solomon, M.B., Loftspring, M., de Kloet, A.D., et al., Neuroendocrine function after hypothalamic depletion of glucocorticoid receptors in male and female mice, Endocrinology, 2015, vol. 156, pp. 2843—2853. 10.1210/en.2015-1276

[2]

Nahar, J., Haam, J., Chen, C., et al., Rapid nongenomic glucocorticoid actions in male mouse hypothalamic neuroendocrine cells are dependent on the nuclear glucocorticoid receptor, Endocrinology, 2015, vol. 156, pp. 2831—2848. 10.1210/en.2015-1273

[3]

Sapolsky, R.M., Romero, L.M., and Munck, A.U., How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions, Endocr. Rev., 2000, 21, pp. 55—89.

[4]

Wang, S.J., Zhao, X.H., Chen, W., et al., Sirtuin 1 activation enhances the PGC-1alpha/mitochondrial antioxidant system pathway in status epilepticus, Mol. Med. Rep., 2015, vol. 11, pp. 521—526. 10.3892/mmr.2014.2724

[5]

Oakley, R.H. and Cidlowski, J.A., Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids, J. Biol. Chem., 2011, vol. 286, pp. 3177—3184. 10.1074/jbc.r110.179325

[6]

Maiaru, M., Tochiki, K.K., Cox, M.B., et al., The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling, Sci. Transl. Med., 2016, vol. 8, p. 325ra19. 10.1126/scitranslmed.aab3376

[7]

D’Alonzo, R., Rigante, D., Mencaroni, E., and Esposito, S., West syndrome: a review and guide for paediatricians, Clin. Drug Invest., 2018, vol. 38, pp. 113—124. 10.1007/s40261-017-0595-z

[8]

Pellock, J.M., Hrachovy, R., Shinnar, S., et al., Infantile spasms: a U.S. consensus report, Epilepsia, 2010, vol. 51, pp. 2175—2189. 10.1111/j.1528-1167.2010.02657.x

[9]

Baram, T.Z., Hirsch, E., Snead, O.C. III, and Schultz, L., Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala, Ann. Neurol., 1992, vol. 31, pp. 488—494. 10.1002/ana.410310505

[10]

Baram, T.Z. and Schultz, L., ACTH does not control neonatal seizures induced by administration of exogenous corticotropin-releasing hormone, Epilepsia, 1995, vol. 36, pp. 174—178. 10.1111/j.1528-1157.1995.tb00977.x

[11]

Maguire, M.J., Hemming, K., Wild, J.M., Hutton, J.L., and Marson, A.G., Prevalence of visual field loss following exposure to vigabatrin therapy: a systematic review, Epilepsia, 2010, vol. 51, pp. 2423—2431. 10.1111/j.1528-1167.2010.02772.x

[12]

Hrachovy, R.A., Frost, J.D., Jr., and Glaze, D.G., High-dose, long-duration versus low-dose, short-duration corticotropin therapy for infantile spasms, J. Pediatr., 1994, vol. 124, pp. 803—806. 10.1016/s0022-3476(05)81379-4

[13]

Hamano, S., Yamashita, S., Tanaka, M., Yoshinari, S., Minamitani, M., and Eto, Y., Therapeutic efficacy and adverse effects of adrenocorticotropic hormone therapy in west syndrome: differences in dosage of adrenocorticotropic hormone, onset of age, and cause, J. Pediatr., 2006, vol. 148, pp. 485—488. 10.1016/j.jpeds.2005.11.041

[14]

Tan, D.X. and Reiter, R.J., Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells, Melatonin Res., 2019, vol. 2, no. 1, pp. 44—66. 10.32794/mr11250011

[15]

Gupta, M., Aneja, S., and Kohli, K., Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: a randomized, double-blind, placebo-controlled trial, Epilepsy Behav., 2004, vol. 5, pp. 316—321. 10.1016/j.yebeh.2004.01.012

[16]

Buscemi, N., Vandermeer, B., Hooton, N., et al., The efficacy and safety of exogenous melatonin for primary sleep disorders: a meta-analysis, J. Gen. Intern. Med., 2005, vol. 20, pp. 1151—1158. 10.1111/j.1525-1497.2005.0243.x

[17]

Chaste, P., Clement, N., Botros, H.G., et al., Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders, J. Pineal Res., 2011, vol. 51, pp. 394—399. 10.1111/j.1600-079x.2011.00902.x

[18]

Doi, M., Hirayama, J., and Sassone-Corsi, P., Circadian regulator CLOCK is a histone acetyltransferase, Cell, 2006, vol. 125, pp. 497—508. 10.1016/j.cell.2006.03.033

[19]

Nader, N., Chrousos, G.P., and Kino, T., Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications, FASEB J., 2009, 23, pp. 1572—1583. 10.1096/fj.08-117697

[20]

Bordone, L. and Guarente, L., Calorie restriction, SIRT1 and metabolism: understanding longevity, Nat. Rev. Mol. Cell Biol., 2005, vol. 6, pp. 298—305. 10.1038/nrm1616

[21]

Xie, J., Zhang, X., and Zhang, L., Negative regulation of inflammation by SIRT1, Pharmacol. Res., 2013, vol. 67, pp. 60—67. 10.1016/j.phrs.2012.10.010

[22]

Feige, J.N. and Auwerx, J., Transcriptional targets of sirtuins in the coordination of mammalian physiology, Curr. Opin. Cell Biol., 2008, vol. 20, pp. 303—309. 10.1016/j.ceb.2008.03.012

[23]

Toorie, A.M., Cyr, N.E., Steger, J.S., Beckman, R., Farah, G. and Nillni, E.A., The nutrient and energy sensor Sirt1 regulates the hypothalamic-pituitary-adrenal (HPA) axis by altering the production of the prohormone convertase 2 (PC2) essential in the maturation of corticotropin-releasing hormone (CRH) from its prohormone in male rats, J. Biol. Chem., 2016, vol. 291, pp. 5844—5859. 10.1074/jbc.m115.675264

[24]

Amat, R., Solanes, G., Giralt, M., and Villarroya, F., SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription, J. Biol. Chem., 2007, vol. 282, pp. 34066—34076. 10.1074/jbc.m707114200

[25]

Chen, Y., Watson, A.M., Williamson, C.D., et al., Glucocorticoid receptor and histone deacetylase-2 mediate dexamethasone-induced repression of MUC5AC gene expression, Am. J. Respir. Cell Mol. Biol., 2012, vol. 47, pp. 637—644. 10.1165/rcmb.2012-0009oc

[26]

Zhang, H., He, Y., Zhang, G., et al., HDAC2 is required by the physiological concentration of glucocorticoid to inhibit inflammation in cardiac fibroblasts, Can. J. Physiol. Pharmacol., 2017, vol. 95, pp. 1030—1038. 10.1139/cjpp-2016-0449

[27]

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen

Methods 2001 10.1006/meth.2001.1262

[28]

Baram, T.Z., Models for infantile spasms: an arduous journey to the Holy Grail, Ann. Neurol., 2007, vol. 61, pp. 89—91. 10.1002/ana.21075

[29]

Velisek, L., Jehle, K., Asche, S., and Veliskova, J., Model of infantile spasms induced by N-methyl-D-aspartic acid in prenatally impaired brain, Ann. Neurol., 2007, vol. 61, pp. 109–119. 10.1002/ana.21082

[30]

Sanchez, E.R., Hsp56: a novel heat shock protein associated with untransformed steroid receptor complexes, J. Biol. Chem., 1990, vol. 265, pp. 22067—22070. 10.1016/s0021-9258(18)45667-0

[31]

Hwang, I.K., Lee, Y.B., Yoo, K.Y., et al., Seizure-induced changes of mineralocorticoid and glucocorticoid receptors in the hippocampus in seizure sensitive gerbils, Neurosci. Res., 2005, vol. 53, pp. 14—24. 10.1016/j.neures.2005.05.006

[32]

Zimmer, C. and Spencer, K.A., Modifications of glucocorticoid receptors mRNA expression in the hypothalamic-pituitary-adrenal axis in response to early-life stress in female Japanese quail, J. Neuroendocrinol., 2014, vol. 26, pp. 853—860. 10.1111/jne.12228

[33]

Kim, H.D., Hesterman, J., Call, T., et al., SIRT1 mediates depression-like behaviors in the nucleus accumbens, J. Neurosci., 2016, vol. 36, pp. 8441—8452. 10.1523/jneurosci.0212-16.2016

[34]

Chen, Y., Xie, Y., Wang, H. and Chen, Y., SIRT1 expression and activity are up-regulated in the brain tissue of epileptic patients and rat models, Nan fang yi ke da xue xue bao, 2013, vol. 33, pp. 528—532.

[35]

Brennan, G.P., Dey, D., Chen, Y., et al., Dual and opposing roles of microRNA-124 in epilepsy are mediated through inflammatory and NRSF-dependent gene networks, Cell Rep., 2016, vol. 14, pp. 2402—2412. 10.1016/j.celrep.2016.02.042

[36]

Barnes, P.J., Transcription factors in airway diseases: laboratory investigation; J. Techn. Methods Pathol., 2006, vol. 86, pp. 867—872.

[37]

Huang, Y., Zhao, F., Wang, L., Yin, H., Zhou, C., and Wang, X., Increased expression of histone deacetylases 2 in temporal lobe epilepsy: a study of epileptic patients and rat models, Synapse (New York, NY), 2012, vol. 66, pp. 151—159. 10.1002/syn.20995

[38]

Ralph, M.R., Foster, R.G., Davis, F.C., and Menaker, M., Transplanted suprachiasmatic nucleus determines circadian period, Science (New York, NY), 1990, vol. 247, pp. 975—978. 10.1126/science.2305266

[39]

Rusak, B. and Zucker, I., Neural regulation of circadian rhythms, Physiol. Rev., 1979, vol. 59, pp. 449—526. 10.1152/physrev.1979.59.3.449

[40]

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

George P. Chrousos

New England Journal of Medicine 1995 10.1056/nejm199505183322008

[41]

Buijs, R.M., van Eden, C.G., Goncharuk, V.D. and Kalsbeek, A., The biological clock tunes the organs of the body: timing by hormones and the autonomic nervous system, J. Endocrinol., 2003, vol. 177, pp. 17—26. 10.1677/joe.0.1770017

[42]

Schibler, U. and Brown, S.A., Enlightening the adrenal gland, Cell Metab., 2005, vol. 2, pp. 278—281. 10.1016/j.cmet.2005.10.001

[43]

Cermakian, N. and Sassone-Corsi, P., Multilevel regulation of the circadian clock, Nat. Rev. Mol. Cell Biol., 2000, vol. 1, pp. 59—67. 10.1038/35036078

[44]

Schibler, U. and Sassone-Corsi, P., A web of circadian pacemakers, Cell, 2002, vol. 111, pp. 919—922. 10.1016/s0092-8674(02)01225-4

[45]

Charmandari, E., Chrousos, G.P., Lambrou, G.I., et al., Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man, PLoS One, 2011, vol. 6. e25612 10.1371/journal.pone.0025612

[46]

Appleton, R.E., Jones, A.P., Gamble, C., et al., The use of melatonin in children with neurodevelopmental disorders and impaired sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS), Health Technol. Assess. (Winchester, England), 2012, vol. 16, p. i-239.

[47]

Gordon, N., The therapeutics of melatonin: a paediatric perspective, Brain Dev., 2000, vol. 22, pp. 213—217. 10.1016/s0387-7604(00)00120-0

[48]

Heussler, H., Chan, P., Price, A.M., Waters, K., Davey, M.J., and Hiscock, H., Pharmacological and non-pharmacological management of sleep disturbance in children: an Australian Paediatric Research Network survey, Sleep Med., 2013, vol. 14, pp. 189—194. 10.1016/j.sleep.2012.09.023

[49]

Wang, Z., Liu, D., Zhan, J., et al., Melatonin improves short and long-term neurobehavioral deficits and attenuates hippocampal impairments after hypoxia in neonatal mice, Pharmacol. Res., 2013, vol. 76, pp. 84—97. 10.1016/j.phrs.2013.07.008

[50]

Jain, S.V., Horn, P.S., Simakajornboon, N., et al., Melatonin improves sleep in children with epilepsy: a randomized, double-blind, crossover study, Sleep Med., 2015, vol. 16, pp. 637—644. 10.1016/j.sleep.2015.01.005

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Published: Feb 01, 2022
Vol/Issue: 58(1)
Pages: 85-93
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University of Science and Technology of China

Cite This Article

G. Yang, L. Wan, S. Zhang, et al. (2022). CLOCK, SIRT1, and HDAC2 Knockdown along with Melatonin Intervention Significantly Decreased the Level Glucocorticoid Receptor. Russian Journal of Genetics, 58(1), 85-93. https://doi.org/10.1134/s1022795422010148

CLOCK, SIRT1, and HDAC2 Knockdown along with Melatonin Intervention Significantly Decreased the Level Glucocorticoid Receptor

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