Vitamin D for the treatment of painful diabetic neuropathy
To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.
Methods
A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.
Results
143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).
Conclusions
Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.
Trial registration number
BIDE-12/2014.
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Paul Lee
D. Shehab, Khaled Al-Jarallah, Nabila Abdella et al.
Gillian A. Hawker, Samra Mian, Tetyana Kendzerska et al.
- Published
- Feb 01, 2016
- Vol/Issue
- 4(1)
- Pages
- e000148
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