journal article Open Access Jan 01, 2021

Excess mortality in adults with documented diabetes in Germany: routine data analysis of all insurance claims in Germany 2013–2014

BMJ Open Vol. 11 No. 1 pp. e041508 · BMJ
View at Publisher Save 10.1136/bmjopen-2020-041508
Abstract
Objectives
Little is known about the age-specific excess mortality pattern of people with diagnosed diabetes in Germany. Thus, our goal was to determine the excess mortality in diagnosed diabetes overall and stratified by age and sex based on claims data.


Design
Routine data analysis using a claims dataset from all statutory health-insured persons in Germany in 2013, which accounts for about 90% of the population.


Participants
We included persons who lived in Germany, were insured at least 360 days, were not self-paying any health services and were aged 30 years or older leading to a total number of 47.3 million insured persons for analyses.


Exposure
Diabetes was determined by the International Classification of Diseases-10 codes E10–E14, which were documented in 2013 in at least two-quarters on an outpatient setting or at least once on an inpatient setting.


Outcome measures
The vital status in the study population was drawn from the claims dataset for the year 2014. We derived the excess mortality estimated as an age-adjusted mortality rate ratio (MRR) by sex and for age groups using a Poisson model.


Main results
We found age-adjusted MRRs (95% CI) for diabetes of 1.52 (1.51 to 1.52) for women and 1.56 (1.56 to 1.56) for men. These figures declined with increasing age and were highest for ages 30–34 years with 6.76 (4.99 to 9.15) for women and 6.87 (5.46 to 8.64) for men, and lowest for age 95 years and older with 1.13 (1.10 to 1.15) for women and 1.11 (1.05 to 1.17) for men.


Conclusions
We derived deeply age-stratified figures on excess mortality in diabetes for Germany. Establishing a sustainable analysis of excess mortality is aimed at within the framework of diabetes surveillance.
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References
26
[2]
Williams "Global trends in type 2 diabetes, 2007-2017" JAMA (2019) 10.1001/jama.2019.16074
[5]
Read "Trends in type 2 diabetes incidence and mortality in Scotland between 2004 and 2013" Diabetologia (2016) 10.1007/s00125-016-4054-9
[7]
Wang "Sex differences in the association between diabetes and risk of cardiovascular disease, cancer, and all-cause and cause-specific mortality: a systematic review and meta-analysis of 5,162,654 participants" BMC Med (2019) 10.1186/s12916-019-1355-0
[8]
Harding JL , Shaw JE , Peeters A . Mortality trends among people with type 1 and type 2 diabetes in Australia: 1997–2010. Diabetes Care 2014:DC_140096. 10.2337/dc14-0096
[9]
Heidemann C , Scheidt-Nave C . Prevalence, incidence and mortality of diabetes mellitus in adults in Germany – a review in the framework of the diabetes Surveillanc: Robert Koch-Institut, Epidemiologie und Gesundheitsberichterstattung 2017.
[10]
Tönnies "Excess mortality for people diagnosed with type 2 diabetes in 2012 – Estimates based on claims data from 70 million Germans" Nutr Metab Cardiovascul Dis (2018) 10.1016/j.numecd.2018.05.008
[11]
German Institute of Medical Documentation and Information (DIMDI) . Health care data. Available: https://www.dimdi.de/dynamic/en/further-services/health-care-data/
[12]
Busse "Statutory health insurance in Germany: a health system shaped by 135 years of solidarity, self-governance, and competition" Lancet (2017) 10.1016/s0140-6736(17)31280-1
[13]
Schmidt "Secondary data in diabetes surveillance – co-operation projects and definition of references on the documented prevalence of diabetes" J Health Monitoring (2019)
[15]
Statistisches Bundesamt . Fachserie 12 Reihe 4. Gesundheit. Todesursachen in Deutschland, 2014. Available: https://www.destatis.de/GPStatistik/receive/DEHeft_heft_00035170
[16]
Fang J . Using SAS® procedures FREQ, GENMOD, logistic, and PHREG to estimate adjusted relative risks – a case study. SAS global forum 2011.
[20]
Baumert J , von der Lippe E , Paprott R , et al . Life expectancy and healthy life years associated with diabetes in Germany. Eur J Public Health 2020;30.doi:10.1093/eurpub/ckaa165.814 10.1093/eurpub/ckaa165.814
[21]
Heidemann "Temporal changes in the prevalence of diagnosed diabetes, undiagnosed diabetes and prediabetes: findings from the German health interview and examination surveys in 1997-1999 and 2008-2011" Diabet Med (2016) 10.1111/dme.13008
[24]
Tamayo "The prevalence and incidence of diabetes in Germany" Dtsch Arztebl Int (2016)
[25]
Ct T , Schwalm A , Mostardt S . Can routine data be used to determine the target population of patients with type 2 diabetes in early benefit assessments in Germany? Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes).
[26]
Bohn "Hospital admission in children and adolescents with or without type 1 diabetes from Germany: an analysis of statutory health insurance data on 12 million subjects" Pediatr Diabetes (2018) 10.1111/pedi.12621