Feelings of loneliness, but not social isolation, predict dementia onset: results from the Amsterdam Study of the Elderly (AMSTEL)

T. J. Holwerda; D. J. H. Deeg; A. T. F. Beekman; T. G. van Tilburg; M. L. Stek; C. Jonker; R. A. Schoevers

doi:10.1136/jnnp-2012-302755

journal article Dec 10, 2012

Feelings of loneliness, but not social isolation, predict dementia onset: results from the Amsterdam Study of the Elderly (AMSTEL)

T. J. Holwerda D. J. H. Deeg A. T. F. Beekman T. G. van Tilburg M. L. Stek C. Jonker R. A. Schoevers

Journal of Neurology, Neurosurgery &amp; Psychiatry Vol. 85 No. 2 pp. 135-142 · BMJ

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References

48

[1]

Kalaria "Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors" Lancet Neurol (2008) 10.1016/s1474-4422(08)70169-8

[2]

Sikkes "Do instrumental activities of daily living predict dementia at 1- and 2- year follow up? Findings from the development of screening guidelines and diagnostic criteria for predementia Alzheimer's Disease Study" J Am Geriatr Soc (2001) 10.1111/j.1532-5415.2011.03732.x

[3]

Steffens "Perspectives on depression, mild cognitive impairment and cognitive decline" Arch Gen Psychiatry (2006) 10.1001/archpsyc.63.2.130

[4]

Geerlings "Depression and risk of cognitive decline and Alzheimer's disease. Results of two perspective community-based studies in the Netherlands" Br J Psychiatry (2000) 10.1192/bjp.176.6.568

[5]

Parker "Neuroendocrine aspects of hypercortisolism in major depression" Horm Behav (2003) 10.1016/s0018-506x(02)00016-8

[6]

Helmer "Marital Status and risk of Alzheimer's disease. A French population-based cohort study" Neurology (1999) 10.1212/wnl.53.9.1953

[7]

Aartsen "Does widowhood affect memory performance of older persons?" Psychol Med (2005) 10.1017/s0033291704002831

[8]

Fratiglioni "Influence of social network on occurrence of dementia: a community-based longitudinal study" Lancet (2000) 10.1016/s0140-6736(00)02113-9

[9]

Barnes "Social resources and cognitive decline in a population of older African Americans and whites" Neurology (2004) 10.1212/01.wnl.0000147473.04043.b3

[10]

Bassuk "Social disengagement and incident cognitive decline in community-dwelling elderly persons" Ann of Intern Med (1999) 10.7326/0003-4819-131-3-199908030-00002

[11]

Wilson "Proneness to psychological distress and risk of Alzheimer disease in a biracial community" Neurology (2005) 10.1212/01.wnl.0000149525.53525.e7

[12]

Loneliness and Risk of Alzheimer Disease

Robert S. Wilson, Kristin R. Krueger, Steven E. Arnold et al.

Archives of General Psychiatry 2007 10.1001/archpsyc.64.2.234

[13]

Bediou "Impaired social cognition in mild Alzheimer Disease" J Geriatr Psychiatry and Neurol (2009) 10.1177/0891988709332939

[14]

Spoletini "Facial emotion recognition deficit in amnestic mild cognitive impairment and Alzheimer disease" Am J Geriatr Psychiatry (2008) 10.1097/jgp.0b013e318165dbce

[15]

Schoevers "Prevention of late life depression in primary care: do we know where to begin?" Am J Psychiatry (2006) 10.1176/appi.ajp.163.9.1611

[16]

Launer "Nonresponse pattern and bias in a community-based cross-sectional study of cognitive functioning among the elderly" Am J Epidemiol (1994) 10.1093/oxfordjournals.aje.a117077

[17]

Launer "Are age and education independent correlates of the Mental State Exam performance of community-dwelling elderly?" J Gerontology (1993) 10.1093/geronj/48.6.p271

[18]

Copeland "A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS AGECAT" Psychol Med (1986) 10.1017/s0033291700057779

[19]

Copeland "Range of mental illness among the elderly in the community. Prevalence in Liverpool using the GMS-AGECAT package" Br J Psychiatry (1987) 10.1192/bjp.150.6.815

[20]

Copeland "Alzheimer's disease, other dementias, depression and pseudodementia: prevalence, incidence and three-year outcome in Liverpool" Br J Psychiatry (1992) 10.1192/bjp.161.2.230

[21]

Roth "CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia" Br J Psychiatry (1986) 10.1192/bjp.149.6.698

[22]

Folstein "“Mini mental state”. A practical method for grading the cognitive state of patients for the clinician" J Psychiatr Res (1975) 10.1016/0022-3956(75)90026-6

[23]

Studies of Illness in the Aged

Sidney Katz

JAMA 1963 10.1001/jama.1963.03060120024016

[24]

Lawton "Assessment of older people: self-maintaining and instrumental activities of daily living" Gerontologist (1969) 10.1093/geront/9.3_part_1.179

[25]

Mc William "The Geriatric Mental State Examination as a case-finding instrument in the community" Br J Psychiatry (1988) 10.1192/bjp.152.2.205

[26]

Copeland "The Geriatric Mental State (GMS) used in the community: replication studies of the computerized diagnosis AGECAT" Psychol Med (1988) 10.1017/s003329170000204x

[27]

Blender "Adjusting for multiple testing—when and how?" J Clin Epid (2001) 10.1016/s0895-4356(00)00314-0

[28]

Scarmeas "Influence of leisure activity on the incidence of Alzheimer's disease" Neurology (2001) 10.1212/wnl.57.12.2236

[29]

Wang "Late life engagement in social and leisure activities associated with decreased risk of dementia" Am J Epidemiol (2002) 10.1093/aje/155.12.1081

[30]

Karp "Mentally stimulating activities at work during midlife and dementia risk after age 75: follow-up study from the Kungsholmen Project" Am J Geriatr Psychiatry (2009) 10.1097/jgp.0b013e318190b691

[31]

Predictors of Cognitive Decline and Mortality of Aged People Over a 10-Year Period

R. S. Tilvis, M. H. Kahonen-Vare, J. Jolkkonen et al.

The Journals of Gerontology Series A: Biological S... 2004 10.1093/gerona/59.3.m268

[32]

Kipps "Emotion, social functioning and activities of daily living in frontotemporal dementia" Neurocase (2009) 10.1080/13554790802632892

[33]

Verdon "Social cognition: an early impairment in dementia of Alzheimer type" Alzheimer Dis Assoc Disord (2006) 10.1097/wad.0b013e318032487a

[34]

Sollberger "Neural basis of interpersonal traits in neurodegenerative diseases" Neuropychologia (2009) 10.1016/j.neuropsychologia.2009.06.006

[35]

Iwasa "Personality and all cause mortality among older adults dwelling in a Japanese community: a five year population based prospective cohort study" Am J Geriatric Psychiatry (2008) 10.1097/jgp.0b013e3181662ac9

[36]

Luanaigh "Loneliness and the health of older people" Int J Geriatr Psychiatry (2008) 10.1002/gps.2054

[37]

De Jong Gierveld "The development of a Rasch-type loneliness-scale" Appl Psychol Meas (1985) 10.1177/014662168500900307

[38]

Russell "Russell. UCLA Loneliness Scale (Version 3): reliability, validity and fracture structure" J Pers Assess (1996) 10.1207/s15327752jpa6601_2

[39]

Victor "Measuring loneliness in later life: a comparison of differing measures" Rev Clin Gerontol (2006) 10.1017/s0959259805001723

[40]

Fees "A model of loneliness in older adults" J Gerontol Psychol Sci (1999) 10.1093/geronb/54b.4.p231

[41]

Kriegsman "Self-reports and general practitioner information on the presence of chronic diseases in community dwelling elderly. A study on the accuracy of patients’ self reports and on determinants of inaccuracy" J Clin Epidemiol (1996) 10.1016/s0895-4356(96)00274-0

[42]

Morgado "Depressed subjects unwittingly overreport poor social adjustment which they reappraise when recovered" J Nerv Ment Dis (1991) 10.1097/00005053-199110000-00005

[43]

Holwerda "Increased risk of mortality associated with social isolation in older men: only when feeling lonely?" Psychol Med (2012) 10.1017/s0033291711001772

[44]

Cahill "‘I hate having nobody here. I'd like to know where they all are”: Can qualitative research detect differences in quality of life among nursing home residents with different levels of cognitive impairment" Aging Ment Health (2011) 10.1080/13607863.2010.551342

[45]

Unverzagt "Incidence and risk factors for Cognitive Impairment No Dementia and Mild Cognitive Impairment in African Americans" Alz Dis Assoc Disord (2011) 10.1097/wad.0b013e3181f1c8b1

[46]

Comijs "The course of cognitive decline in older persons: results from the Longitudinal Aging Study Amsterdam" Dement Geriatr Cogn Disord (2004) 10.1159/000076346

[47]

Van Boxtel "The relation between morbidity and cognitive performance in a normal aging population" J Geront A Biol Sci Med Sci (1998) 10.1093/gerona/53a.2.m147

[48]

Comijs "The impact of change in cognitive functioning and cognitive decline on disability, well being, and the use of healthcare services in older persons. Results from the Longitudinal Aging Study Amsterdam" Dement Geriatr Cogn Disord (2005) 10.1159/000084557

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References

Details

Published: Dec 10, 2012
Vol/Issue: 85(2)
Pages: 135-142

Authors

Cite This Article

T. J. Holwerda, D. J. H. Deeg, A. T. F. Beekman, et al. (2012). Feelings of loneliness, but not social isolation, predict dementia onset: results from the Amsterdam Study of the Elderly (AMSTEL). Journal of Neurology, Neurosurgery &amp; Psychiatry, 85(2), 135-142. https://doi.org/10.1136/jnnp-2012-302755

Feelings of loneliness, but not social isolation, predict dementia onset: results from the Amsterdam Study of the Elderly (AMSTEL)

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