Epidemiology of peripheral neuropathy.

C N Martyn; R A Hughes

doi:10.1136/jnnp.62.4.310

journal article Apr 01, 1997

Epidemiology of peripheral neuropathy.

C N Martyn R A Hughes

Journal of Neurology, Neurosurgery &amp; Psychiatry Vol. 62 No. 4 pp. 310-318 · BMJ

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References

105

[1]

Guillain-Barre syndrome (GBS) has been the subject of over 30 population studies during the past 50 years, most of which have shown an annual incidence in the range 1 0 to 2 0 per 100 000 population. The condition seems to be reasonably evenly distributed throughout the world and incidence rates are probably fairly stable over time.26 The annual incidence seemed to rise from 1-2 per 100 000 in 1953-6 to 2-7 per 100 000 in 1970-80 in Olmsted county, Rochester, USA.27 Similarly the annual incidence rose from about 1-3 per 100 000 in the triennium 1981-3 to 2-7 per 100 000 in 1991-3 when surveyed in Ferrara, northern Italy.28 These apparent increases in incidence were based on few cases and may be explained by increasing awareness and ascertainment of the disease.28

[2]

The disease occurs from infancy to extreme old age. There is a more or less linear increase in incidence with advancing years which would be compatible with lessening of immune suppressor mechanisms in old age and consequent increased susceptibility to autoimmune disease. In the largest series, collected in an active surveillance programme in the United States from 1979 to 1981, there was a small peak in the age distribution for young adults, especially women.32 This might be explained by exposure to infections which are more common in that age group, which include Campylobacter jejuni and cytomegalovirus.

[3]

relation between the onset of symptoms and However, there are also other explanations for cytomegalovirus infection. Neuropathies in the association between a paraprotein and the other patients were more heterogenous. neuropathy including amyloid, vasculitis, and They included multiple mononeuropathy, isocoincidence. Peripheral neuropathy is somelated mononeuropathies, and lumbosacral times a feature of multiple myeloma, and is polyradiculopathy.

[4]

Organisation surveillance programmes are plasm. Conversely between 2 5 and 5 5% of having a major impact. Between 1990 and patients with lung or breast cancer have clinical

[5]

there was a 55% fall in the worldwide evidence of a peripheral neuropathy.74 Focal or prevalence although part of the decrease may multifocal radiculopathies, plexopathies, and be due to changes in case definition. The highneuropathies are usually due to infiltration or est prevalence of leprosy is in South East Asia compression by the tumour. When symmetric

[6]

Recognition of the association between the Occupational exposure to solvents such as

[7]

sulphate-3-glucuronyl paragloboside. Transfer Occasional outbreaks of neuropathy caused by of the serum from patients with these antibodindustrial exposure are reported in economiies has induced experimental demyelinating cally developing countries. The epidemic of neuropathy in animals and there are anecdotal Jamaica ginger paralysis that occurred in the reports of improvement after treatment with United States in 1930 and 1931 was due to the contamination of illicit alcohol with tri-ocresyl phosphate. The story is an interesting one-not least because of the scale of the outbreak. It is estimated that 50 000 people were affected.76 Other sudden outbreaks of peripheral neuropathy due to tri-o-cresyl phosphate have been reported in India, South Africa, and Morocco.77-79

[8]

In a large cohort of women followed up in the Oxford Family Planning Association contraceptive study, carpal tunnel syndrome was associated with obesity and a history of menstrual disorders. There was also a strong and unexpected association with smoking.

[9]

Cervical radiculopathy Cervical radiculopathy is another disorder of the peripheral nervous system that is common in clinical neurological practice but which has hardly been studied epidemiologically. The best information again comes from the Mayo clinic's medical record linkage system. Between 1976 and 1990, 561 patients from the population of Rochester and Olmsted county were diagnosed as having cervical radiculopathy. The overall annual incidence was 83 per 100 000 and rates were higher in men than in women.98 Incidence was highest in the age group 50 to 54 years. The C6 or C7 nerve roots were affected in 64% of cases. Although recurrence of symptoms was common 32% of patients reported recurrence during a median time of follow up of five years-90% had few or no symptoms at their last follow up. Although population based, case finding in this study depended on medical records and it is almost certain that mild cases of the condition were underrepresented.

[10]

Beghi E, Monticelli ML, Amoruso L, et al. Chronic symmetrical polyneuropathy in the elderly-a field screening investigation in 2 Italian regions 1. Prevalence and general characteristics of the sample. Neurology 1995;45: 1832-6. 10.1212/wnl.45.10.1832

[11]

Bharucha NE, Bharucha AE, Bharucha EP. Prevalence of peripheral neuropathy in the Parsi community of Bombay. Neurology 1991;41:1315-7. 10.1212/wnl.41.8.1315

[12]

Savettieri G, Rocca WA, Salemi G, et al. Prevalence of diabetic neuropathy with somatic symptoms: a door-to-door survey in two Sicilian municipalities. Neurology 1993;43: 1115-20. 10.1212/wnl.43.6.1115

[13]

Palumbo PJ, Elvehack LR, Whisnant JP. Neurological complications of diabetes mellitus: transient ischaemic attack, stroke and peripheral neuropathy. In: Schoenberg BS, ed. Neurological epidemiology: principles and clinical applications. New York: Raven Press, 1978:593-601.

[14]

Maser RE, Steenkiste AR, Dorman JS, et al. Epidemiological correlates of diabetic neuropathy: report from Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes 1989;38:1456-61. 10.2337/diab.38.11.1456

[15]

Franklin GM, Kahn LB, Baxter J, Marshall JA, Hamman RF. Sensory neuropathy in non-insulin-dependent diabetes mellitus: the San Luis Valley Diabetes Study. Am _7 Epidemiol 1990;131:633-43. 10.1093/oxfordjournals.aje.a115547

[16]

Partanen J, Niskanen L, Lehtinen J, Mervaala E, Siitonen 0, Uusitupa M. Natural history of peripheral neuropathy in patients with non-insulin-dependent diabetes mellitus. NEnglJ7Med 1995;333:89-94.

[17]

Orchard TJ, Dorman JS, Maser RE, et al. Prevalence of complications in IDDM by sex and duration. Pittsburgh Epidemiology of Diabetes Complications Study II. Diabetes 1990;39:1116-24. 10.2337/diab.39.9.1116

[18]

DCCT Research Group. The effect of intensive diabetes therapy on the development and progression of neuropathy. Ann Intern Med 1995;122:561-8. 10.7326/0003-4819-122-8-199504150-00001

[19]

Albers JW, Kenny DJ, Brown M, et al. Effect of intensive diabetes treatment on nerve conduction in the diabetes control and complications trial. Ann Neurol 1995;38: 869-80. 10.1002/ana.410380607

[20]

Neil HA, Thompson AV, John S, McCarthy ST, Mann JI. Diabetic autonomic neuropathy: the prevalence of impaired heart rate variability in a geographically defined population. Diabet Med 1989;6:20-4. Epidemiologyofpenipheral neuropathy 10.1111/j.1464-5491.1989.tb01133.x

[21]

Ewing DJ, Campbell IW, Clarke BF. The natural history of diabetic autonomic neuropathy. Q Jf Med 1980;49: 95-108.

[22]

Flynn MD, O'Brien IA, Corrall RJM. The prevalence of autonomic and peripheral neuropathy in insulin-treated diabetic subjects. Diabet Med 1995;12:310-3. 10.1111/j.1464-5491.1995.tb00483.x

[23]

Fleckenstein JF, Frank SM, Thuluvath PJ. Presence of autonomic neuropathy is a poor prognostic indicator in patients with advanced liver disease. Hepatology 1996;23: 471-5. 10.1002/hep.510230311

[24]

Descriptive epidemiology of selected neuromuscular disorders in Benghazi, Libya

K. Radhakrishnan, M. A. El-Mangoush, S. E. Gerryo

Acta Neurologica Scandinavica 1987 10.1111/j.1600-0404.1987.tb07901.x

[25]

Osuntokun BO, Adeuja AOG, Schoenberg BS, et al. Neurological disorders in Nigerian Africans: a community-based study. Acta Neurol Scand 1987;75:13-21. 10.1111/j.1600-0404.1987.tb07883.x

[26]

MacMillan JC, Harper PS. The Charcot-Marie-Tooth syndrome: clinical aspects from a population study in South Wales, UK. Clinical Genetics 1994;45:128-34. 10.1111/j.1399-0004.1994.tb04009.x

[27]

Hagberg B, Westerberg B. Hereditary motor and sensory neuropathies in Swedish children. I. Prevalence and distribution by disability groups. Acta Paediatrica Scandinavica 1983;72:379-83. 10.1111/j.1651-2227.1983.tb09732.x

[28]

Holmberg BH. Charcot-Marie-Tooth disease in northern Sweden: an epidemiological and clinical study. Acta Neurol Scand 1993;87:416-22. 10.1111/j.1600-0404.1993.tb04127.x

[29]

Combarros 0, Calleja J, Polo JM, Berciano J. Prevalence of hereditary motor and sensory neuropathy in Cantabria. Acta Neurol Scand 1987;75:9-12. 10.1111/j.1600-0404.1987.tb07882.x

[30]

Genetic and clinical aspects of Charcot‐Marie‐Tooth's disease

H. Skre

Clinical Genetics 1974 10.1111/j.1399-0004.1974.tb00638.x

[31]

Nelis E, van Broeckhoven C. Estimation of the mutation frequencies in Charcot-Marie-Tooth disease type 1 and hereditary neuropathy with liability to pressure palsies: a European collaborative study. Eur Hum Genet 1996;4: 25-33. 10.1159/000472166

[32]

Blair IP, Nash J, Gordon MJ, Nicholson GA. Prevalence and origin of de novo duplications in Charcot-MarieTooth disease type 1A: first report of a de novo duplication with a maternal origin. Am J Hum Genet 1996;58: 472-6.

[33]

Holmberg BH, Holmgren G, Nelis E, van Broeckhoven C, Westerberg B. Charcot-Marie-Tooth disease in northern Sweden: pedigree analysis and the presence of the duplication in chromosome 17pl1-2. Jf Med Genet 1994;31: 435-41. 10.1136/jmg.31.6.435

[34]

Reilly M, Staunton H. Peripheral nerve amyloidosis. Brain Pathol 1996;6: 163-77. 10.1111/j.1750-3639.1996.tb00798.x

[35]

Hughes RAC, Rees JH. Clinical and epidemiological features of Guillain-Barre syndrome. 1996 (in press).

[36]

Guillain-Barre syndrome: clinicoepidemologic features and effect of influenza vaccine. Arch Neurol 1996;42: 1053-7.

[37]

Govoni V, Granieri E, Casetta I, et al. The incidence of Guillain-Barre syndrome in Ferrara, Italy: is the disease really increasing? J Neurol Sci 1996;137:62-8. 10.1016/0022-510x(95)00333-w

[38]

Rees JH, Thompson RD, Hughes RAC. An epidemiological study of Guillain-Barre syndrome. JfNeurol Neurosurg Psychiatry 1996;61:215.

[39]

Asbury AK, Cormblath DR. Assessment of current diagnostic criteria for Guillain-Barre syndrome. Ann Neurol 1990;27(suppl):S21-4. 10.1002/ana.410270707

[40]

Rees JH, Soudain SE, Gregson NA, Hughes RAC. A prospective case control study to investigate the relationship between Campylobacter jejuni infection and GuillainBarre syndrome. NEnglJMed 1995;333:1374-9.

[41]

Kaplan JE, Katona P, Hurwitz ES, Schonberger LB. Guillain-Barre syndrome in the United States, 1979-80 and 1980-1. Lack of an association with influenza vaccination. JAMA 1982;248:698-700. 10.1001/jama.1982.03330060038030

[42]

Guillain-Barre syndrome in the United States 1978-81; additional observations from the national surveillance system. Neurology 1983;33:633-7. 10.1212/wnl.33.5.633

[43]

Barna M, Komatsu T, Zhengbiao B, Reiss CS. Sex differences in susceptibility to viral infection of the central nervous system. Neuroimmunol 1996;67:31-9. 10.1016/0165-5728(96)00022-7

[44]

Roman GC. Tropical neuropathies. In: Hartung H-P, ed. Peripheral neuropathies: part 1. London: Bailliere Tindall 1995;469-87.

[45]

Khoury SA. Guillain-Barre syndrome: epidemiology of an outbreak. Am _J Epidemiol 1978;197:433-8. 10.1093/oxfordjournals.aje.a112561

[46]

McKhann GM, Cornblath DR, Griffin JW, et al. Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol 1993;33:333-42. 10.1002/ana.410330402

[47]

Ho TW, Mishu B, Li CY, et al. Guillain-Barre syndrome in northern China. Relationship to Campylobacter jejuni infection and anti-glycolipid antibodies. Brain 1995; 118:597-605. 10.1093/brain/118.3.597

[48]

Winer JB, Hughes RAC, Anderson MJ, Jones DM, Kangro H, Watkins RFP. A prospective study of acute idiopathic neuropathy. II. Antecedent events. Neurol Neurosurg Psychiatry 1988;51:613-8. 10.1136/jnnp.51.5.613

[49]

Van der Meche FGA, Schmitz PIM, Dutch Guillain-Barre Study Group. A randomized trial comparing intravenous immune globulin and plasma exchange in Guillain-Barre syndrome. NEnglJ7Med 1992;326:1 123-9.

[50]

Mishu B, Ilyas A, Koski C, et al. Serologic evidence of previous Campylobacter jejuni infection in patients with Guillain-Barre syndrome. Ann Intern Med 1993;118: 947-53. 10.7326/0003-4819-118-12-199306150-00006

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Published: Apr 01, 1997
Vol/Issue: 62(4)
Pages: 310-318

Authors

Cite This Article

C N Martyn, R A Hughes (1997). Epidemiology of peripheral neuropathy.. Journal of Neurology, Neurosurgery &amp; Psychiatry, 62(4), 310-318. https://doi.org/10.1136/jnnp.62.4.310

Epidemiology of peripheral neuropathy.

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