Siderophore production by Proteus mirabilis

Lisa P. Evanylo; Solomon Kadis; James R. Maudsley

doi:10.1139/m84-163

journal article Aug 01, 1984

Siderophore production by Proteus mirabilis

Lisa P. Evanylo Solomon Kadis James R. Maudsley

Canadian Journal of Microbiology Vol. 30 No. 8 pp. 1046-1051 · Canadian Science Publishing

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Abstract

Studies on the isolation and characterization of Proteus mirabilis siderophores provided no evidence that these bacteria synthesize catechol- or hydroxamate-type siderophores. However, gas chromatograph analysis in conjunction with mass spectroscopy revealed the presence of α-hydroxyisovaleric acid, a previously unknown metabolite. Additional substantiating evidence for the presence of α-hydroxyisovaleric acid in these bacteria was obtained from experiments involving the use of thin-layer chromatography and an ultraviolet absorption spectrum. This compound was found to be capable of removing iron from the synthetic chelator, ethylene-diamine-di-orthohydroxyphenyl acetic acid, and supplying that iron to the bacteria both in a solid agar medium and in a liquid medium. Proteus mirabilis was found to possess an enzyme capable of catalyzing the reaction by which α-hydroxyisovaleric acid is converted to α-ketoisovaleric acid, an intermediate in the valine biosynthetic pathway.

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Details

Published: Aug 01, 1984
Vol/Issue: 30(8)
Pages: 1046-1051
License: View

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Cite This Article

Lisa P. Evanylo, Solomon Kadis, James R. Maudsley (1984). Siderophore production by Proteus mirabilis. Canadian Journal of Microbiology, 30(8), 1046-1051. https://doi.org/10.1139/m84-163

Siderophore production by Proteus mirabilis

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