Predictive Processing: A Circuit Approach to Psychosis

Georg B. Keller; Philipp Sterzer

doi:10.1146/annurev-neuro-100223-121214

journal article Open Access Aug 08, 2024

Predictive Processing: A Circuit Approach to Psychosis

Georg B. Keller Philipp Sterzer

Annual Review of Neuroscience Vol. 47 No. 1 pp. 85-101 · Annual Reviews

View at Publisher Save 10.1146/annurev-neuro-100223-121214

Abstract

Predictive processing is a computational framework that aims to explain how the brain processes sensory information by making predictions about the environment and minimizing prediction errors. It can also be used to explain some of the key symptoms of psychotic disorders such as schizophrenia. In recent years, substantial advances have been made in our understanding of the neuronal circuitry that underlies predictive processing in cortex. In this review, we summarize these findings and how they might relate to psychosis and to observed cell type–specific effects of antipsychotic drugs. We argue that quantifying the effects of antipsychotic drugs on specific neuronal circuit elements is a promising approach to understanding not only the mechanism of action of antipsychotic drugs but also psychosis. Finally, we outline some of the key experiments that should be done. The aims of this review are to provide an overview of the current circuit-based approaches to psychosis and to encourage further research in this direction.

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References

115

[1]

"Computational psychiatry: towards a mathematically informed understanding of mental illness" J. Neurol. Neurosurg. Psychiatry (2016)

[2]

"The computational anatomy of psychosis" Front. Psychiatry (2013)

[3]

"Early-course unmedicated schizophrenia patients exhibit elevated prefrontal connectivity associated with longitudinal change" J. Neurosci. (2015) 10.1523/jneurosci.2310-14.2015

[4]

"Self-supervised learning from images with a joint-embedding predictive architecture" (2023)

[5]

"Visuomotor coupling shapes the functional development of mouse visual cortex" Cell (2017) 10.1016/j.cell.2017.05.023

[6]

Some informational aspects of visual perception.

Fred Attneave

Psychological Review 1954 10.1037/h0054663

[7]

"Stimulus-specific prediction error neurons in mouse auditory cortex" (2023)

[8]

"Layer-specific integration of locomotion and sensory information in mouse barrel cortex" Nat. Commun. (2019) 10.1038/s41467-019-10564-8

[9]

"Possible principles underlying the transformations of sensory messages" (1961)

[10]

Prediction and memory: A predictive coding account

Helen C. Barron, Ryszard Auksztulewicz, Karl Friston

Progress in Neurobiology 2020 10.1016/j.pneurobio.2020.101821

[11]

Canonical Microcircuits for Predictive Coding

Andre M. Bastos, W. Martin Usrey, Rick A. Adams et al.

Neuron 2012 10.1016/j.neuron.2012.10.038

[12]

"General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons" Neuron (2022) 10.1016/j.neuron.2022.03.032

[13]

"Laminar differences in gamma and alpha coherence in the ventral stream" PNAS (2011) 10.1073/pnas.1011284108

[14]

Whatever next? Predictive brains, situated agents, and the future of cognitive science

Andy Clark

Behavioral and Brain Sciences 2013 10.1017/s0140525x12000477

[15]

"Deep cortical layers are activated directly by thalamus" Science (2013) 10.1126/science.1236425

[16]

"Hallucinations and strong priors" Trends Cogn. Sci. (2019) 10.1016/j.tics.2018.12.001

[17]

"Molecular imaging of schizophrenia: neurochemical findings in a heterogeneous and evolving disorder" Behav. Brain Res. (2021) 10.1016/j.bbr.2020.113004

[18]

"Efficient coding of natural scenes in the lateral geniculate nucleus: experimental test of a computational theory" J. Neurosci. (1996) 10.1523/jneurosci.16-10-03351.1996

[19]

"A functional microcircuit for cat visual cortex" J. Physiol. (1991) 10.1113/jphysiol.1991.sp018733

[20]

"The genetic determinants of language network dysconnectivity in drug-naïve early stage schizophrenia" NPJ Schizophr (2021) 10.1038/s41537-021-00141-8

[21]

"Cortical output is gated by horizontally projecting neurons in the deep layers" Neuron (2020) 10.1016/j.neuron.2019.10.011

[22]

"Neural substrates of vocalization feedback monitoring in primate auditory cortex" Nature (2008) 10.1038/nature06910

[23]

Efference Copy and Corollary Discharge: Implications for Thinking and Its Disorders*

I. Feinberg

Schizophrenia Bulletin 1978 10.1093/schbul/4.4.636

[24]

"Distributed hierarchical processing in the primate cerebral cortex" Cereb. Cortex (1991)

[25]

"The doxastic shear pin: delusions as errors of learning and memory" Cogn. Neuropsychiatry (2016) 10.1080/13546805.2015.1136206

[26]

"The temporal precision of reward prediction in dopamine neurons" Nat. Neurosci. (2008) 10.1038/nn.2159

[27]

"Experience-dependent spatial expectations in mouse visual cortex" Nat. Neurosci. (2016) 10.1038/nn.4385

[28]

"Perceiving is believing: a Bayesian approach to explaining the positive symptoms of schizophrenia" Nat. Rev. Neurosci. (2009) 10.1038/nrn2536

[29]

"Prefrontal and striatal dopamine release are inversely correlated in schizophrenia" Biol. Psychiatry (2022) 10.1016/j.biopsych.2022.05.009

[30]

A theory of cortical responses

Karl Friston

Philosophical Transactions of the Royal Society B:... 2005 10.1098/rstb.2005.1622

[31]

Experiences of alien control in schizophrenia reflect a disorder in the central monitoring of action

Christopher D. Frith, D. John Done

Psychological Medicine 1989 10.1017/s003329170001240x

[32]

"Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders" Curr. Mol. Med. (2015) 10.2174/1566524015666150303003028

[33]

"A cortical circuit for audio-visual predictions" Nat. Neurosci. (2022) 10.1038/s41593-021-00974-7

[34]

"Microcircuitry of the visual cortex" Annu. Rev. Neurosci. (1983) 10.1146/annurev.ne.06.030183.001245

[35]

"Review of thalamocortical resting-state fMRI studies in schizophrenia" Schizophr. Res. (2017) 10.1016/j.schres.2016.08.005

[36]

"Bootstrap your own latent: a new approach to self-supervised learning" (2020)

[37]

"Influence of prior beliefs on perception in early psychosis: effects of illness stage and hierarchical level of belief" J. Abnorm. Psychol. (2020) 10.1037/abn0000494

[38]

"Corticostriatal circuitry" Dialogues Clin. Neurosci. (2016) 10.31887/dcns.2016.18.1/shaber

[39]

"Mouse motor cortex coordinates the behavioral response to unpredicted sensory feedback" Neuron (2018) 10.1016/j.neuron.2018.07.046

[40]

"Antipsychotic drugs selectively decorrelate long-range interactions in deep cortical layers" eLife (2023)

[41]

"Dopaminergic dysfunction in alcoholism and schizophrenia—psychopathological and behavioral correlates" Eur. Psychiatry J. Assoc. Eur. Psychiatr. (2002) 10.1016/s0924-9338(02)00628-4

[42]

"Towards a unifying cognitive, neurophysiological, and computational neuroscience account of schizophrenia" Schizophr. Bull. (2019) 10.1093/schbul/sby154

[43]

"The formation of maintenance of delusions: a Bayesian analysis" Br. J. Psychiatry J. Ment. Sci. (1986) 10.1192/bjp.149.1.51

[44]

"The dopamine hypothesis of schizophrenia: version III—the final common pathway" Schizophr. Bull. (2009) 10.1093/schbul/sbp006

[45]

"Integrating the neurodevelopmental and dopamine hypotheses of schizophrenia and the role of cortical excitation-inhibition balance" Biol. Psychiatry (2022) 10.1016/j.biopsych.2022.06.017

[46]

"Convergence of cortical and thalamic input to direct and indirect pathway medium spiny neurons in the striatum" Brain Struct. Funct. (2014) 10.1007/s00429-013-0601-z

[47]

"Potential mechanisms underlying the therapeutic effects of electroconvulsive therapy" Neurosci. Bull. (2016)

[48]

"Forward models: supervised learning with a distal teacher" Cogn. Sci. (1992) 10.1207/s15516709cog1603_1

[49]

"Opposing influence of top-down and bottom-up input on excitatory layer 2/3 neurons in mouse primary visual cortex" Neuron (2020) 10.1016/j.neuron.2020.09.024

[50]

"The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity" eLife (2023) 10.7554/elife.85111

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Details

Published: Aug 08, 2024
Vol/Issue: 47(1)
Pages: 85-101
License: View

Authors

G

Georg B. Keller

1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland; email: georg.keller@fmi.ch; 2Faculty of Natural Science, University of Basel, Basel, Switzerland

P

Philipp Sterzer

3Department of Psychiatry, University of Basel, Basel, Switzerland

Cite This Article

Georg B. Keller, Philipp Sterzer (2024). Predictive Processing: A Circuit Approach to Psychosis. Annual Review of Neuroscience, 47(1), 85-101. https://doi.org/10.1146/annurev-neuro-100223-121214

Predictive Processing: A Circuit Approach to Psychosis

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