Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb

Ioannis I. Lazaridis; Angela J. T. Bosch; Lena Keller; Andy J. Y. Low; Jeanne Tamarelle; Seraina O. Moser; Denise V. Winter; CRISTINA GÓMEZ; Caspar J. Peterson; Romano Schneider; Marko Kraljević; Alex Odermatt; Pascale Vonaesch; Ralph Peterli; Tarik Delko; Claudia Cavelti-Weder

doi:10.1152/ajpendo.00327.2023

journal article Jun 01, 2024

Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb

Ioannis I. Lazaridis

Angela J. T. Bosch Lena Keller Andy J. Y. Low Jeanne Tamarelle Seraina O. Moser Denise V. Winter

CRISTINA GÓMEZ

Caspar J. Peterson Romano Schneider Marko Kraljević Alex Odermatt

Pascale Vonaesch

Ralph Peterli Tarik Delko Claudia Cavelti-Weder

American Journal of Physiology-Endocrinology and Metabolism Vol. 326 No. 6 pp. E819-E831 · American Physiological Society

View at Publisher Save 10.1152/ajpendo.00327.2023

Abstract

Weight loss following OAGB surgery in obese mice was not influenced by BPL length, but a longer BPL was associated with improved metabolic outcomes, including glucose and lipid homeostasis. These changes could be mediated by bile acids upon altered gut microbiota. Further validation of these findings is required through a randomized human study.

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Metrics

7

Citations

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References

Details

Published: Jun 01, 2024
Vol/Issue: 326(6)
Pages: E819-E831

Authors

I

Ioannis I. Lazaridis

Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland

A

Angela J. T. Bosch

Department of Biomedicine (DBM), University of Basel, University Hospital Basel, Basel, Switzerland; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland

L

Lena Keller

Department of Biomedicine (DBM), University of Basel, University Hospital Basel, Basel, Switzerland; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland

A

Andy J. Y. Low

Department of Biomedicine (DBM), University of Basel, University Hospital Basel, Basel, Switzerland; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland

J

Jeanne Tamarelle

Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland

S

Seraina O. Moser

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

D

Denise V. Winter

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

C

CRISTINA GÓMEZ

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

C

Caspar J. Peterson

Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland

R

Romano Schneider

Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland

M

Marko Kraljević

Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland

A

Alex Odermatt

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

P

Pascale Vonaesch

Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland

R

Ralph Peterli

Clarunis, Department of Visceral Surgery, University Center for Gastrointestinal and Liver Diseases, St. Clara Hospital and University Hospital Basel, Basel, Switzerland; Department of Clinical Research, University of Basel, Basel, Switzerland

T

Tarik Delko

Chirurgie Zentrum St. Anna, Lucerne, Switzerland

C

Claudia Cavelti-Weder

Department of Biomedicine (DBM), University of Basel, University Hospital Basel, Basel, Switzerland; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland

Funding

Swiss National Science Foundation Award: 32003B_204937 / 2

Freie Akademische Gesellschaft Basel

Nora von Meeuwen-Häfliger Stiftung

Cite This Article

Ioannis I. Lazaridis, Angela J. T. Bosch, Lena Keller, et al. (2024). Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb. American Journal of Physiology-Endocrinology and Metabolism, 326(6), E819-E831. https://doi.org/10.1152/ajpendo.00327.2023

Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb

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