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journal article Jul 01, 2013

Amygdala inputs drive feedforward inhibition in the medial prefrontal cortex

Jonathan Dilgen Hugo A. Tejeda ORCID Patricio O'Donnell
Journal of Neurophysiology Vol. 110 No. 1 pp. 221-229 · American Physiological Society
View at Publisher Save 10.1152/jn.00531.2012
Abstract
Although interactions between the amygdala and prefrontal cortex (PFC) are critical for emotional guidance of behavior, the manner in which amygdala affects PFC function is not clear. Whereas basolateral amygdala (BLA) output neurons exhibit many characteristics associated with excitatory neurotransmission, BLA stimulation typically inhibits PFC cell firing. This apparent discrepancy could be explained if local PFC inhibitory interneurons were activated by BLA inputs. Here, we used in vivo juxtacellular and intracellular recordings in anesthetized rats to investigate whether BLA inputs evoke feedforward inhibition in the PFC. Juxtacellular recordings revealed that BLA stimulation evoked action potentials in PFC interneurons and silenced most pyramidal neurons. Intracellular recordings from PFC pyramidal neurons showed depolarizing postsynaptic potentials, with multiple components evoked by BLA stimulation. These responses exhibited a relatively negative reversal potential (Erev), suggesting the contribution of a chloride component. Intracellular administration or pressure ejection of the GABA-A antagonist picrotoxin resulted in action-potential firing during the BLA-evoked response, which had a more depolarized Erev. These results suggest that BLA stimulation engages a powerful inhibitory mechanism within the PFC mediated by local circuit interneurons.
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References
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Dopaminergic Regulation of Inhibitory and Excitatory Transmission in the Basolateral Amygdala–Prefrontal Cortical Pathway

Stan B. Floresco, Maric T. Tse

The Journal of Neuroscience 10.1523/jneurosci.5474-06.2007
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Cited By
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Neuroscience & Biobehavioral Re...
Metrics
90
Citations
32
References
Details
Published
Jul 01, 2013
Vol/Issue
110(1)
Pages
221-229
Authors
J
Jonathan Dilgen

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland; and

H
Hugo A. Tejeda

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland; and

P
Patricio O'Donnell

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland; and; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland

Cite This Article
Jonathan Dilgen, Hugo A. Tejeda, Patricio O'Donnell (2013). Amygdala inputs drive feedforward inhibition in the medial prefrontal cortex. Journal of Neurophysiology, 110(1), 221-229. https://doi.org/10.1152/jn.00531.2012
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