Histamine in the Nervous System

Helmut L. Haas; Olga A. Sergeeva; Oliver Selbach

doi:10.1152/physrev.00043.2007

journal article Jul 01, 2008

Histamine in the Nervous System

Helmut L. Haas Olga A. Sergeeva Oliver Selbach

Physiological Reviews Vol. 88 No. 3 pp. 1183-1241 · American Physiological Society

View at Publisher Save 10.1152/physrev.00043.2007

Abstract

Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the skin, and the immune system. Histaminergic neurons in mammalian brain are located exclusively in the tuberomamillary nucleus of the posterior hypothalamus and send their axons all over the central nervous system. Active solely during waking, they maintain wakefulness and attention. Three of the four known histamine receptors and binding to glutamate NMDA receptors serve multiple functions in the brain, particularly control of excitability and plasticity. H1 and H2 receptor-mediated actions are mostly excitatory; H3 receptors act as inhibitory auto- and heteroreceptors. Mutual interactions with other transmitter systems form a network that links basic homeostatic and higher brain functions, including sleep-wake regulation, circadian and feeding rhythms, immunity, learning, and memory in health and disease.

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Metrics

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Citations

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References

Details

Published: Jul 01, 2008
Vol/Issue: 88(3)
Pages: 1183-1241

Authors

Cite This Article

Helmut L. Haas, Olga A. Sergeeva, Oliver Selbach (2008). Histamine in the Nervous System. Physiological Reviews, 88(3), 1183-1241. https://doi.org/10.1152/physrev.00043.2007

Histamine in the Nervous System

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