Rho GTPase signaling in cancer progression and dissemination

Eva Crosas-Molist; Remi Samain; Leonie Kohlhammer; Jose L. Orgaz; Samantha L. George; Oscar Maiques; Jaume Barcelo; Victoria Sanz-Moreno

doi:10.1152/physrev.00045.2020

journal article Jan 01, 2022

Rho GTPase signaling in cancer progression and dissemination

Eva Crosas-Molist Remi Samain Leonie Kohlhammer Jose L. Orgaz Samantha L. George Oscar Maiques Jaume Barcelo Victoria Sanz-Moreno

Physiological Reviews Vol. 102 No. 1 pp. 455-510 · American Physiological Society

View at Publisher Save 10.1152/physrev.00045.2020

Abstract

Rho GTPases are a family of small G proteins that regulate a wide array of cellular processes related to their key roles controlling the cytoskeleton. Cancer is a multistep disease caused by the accumulation of genetic mutations and epigenetic alterations, from the initial stages of cancer development when cells in normal tissues undergo transformation, to the acquisition of invasive and metastatic traits, responsible for a large number of cancer related deaths. In this review, we discuss the role of Rho GTPase signaling in cancer in every step of disease progression. Rho GTPases contribute to tumor initiation and progression, by regulating proliferation and apoptosis, but also metabolism, senescence, and cancer cell stemness. Rho GTPases play a major role in cell migration and in the metastatic process. They are also involved in interactions with the tumor microenvironment and regulate inflammation, contributing to cancer progression. After years of intensive research, we highlight the importance of relevant models in the Rho GTPase field, and we reflect on the therapeutic opportunities arising for cancer patients.

Topics

No keywords indexed for this article. Browse by subject →

References

553

[1]

The Hallmarks of Cancer

Douglas Hanahan, Robert A Weinberg

Cell 10.1016/s0092-8674(00)81683-9

[2]

Hallmarks of Cancer: The Next Generation

Douglas Hanahan, Robert A. Weinberg

Cell 10.1016/j.cell.2011.02.013

[3]

10.4161/sgtp.29019

[4]

10.1016/j.tcb.2006.08.006

[5]

10.1038/nrm.2016.67

[6]

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Paul M. Müller, Juliane Rademacher, Richard D. Bagshaw et al.

Nature Cell Biology 10.1038/s41556-020-0488-x

[7]

10.1038/s41556-019-0438-7

[8]

10.1016/j.tcb.2006.11.004

[9]

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

D R Cook, K L Rossman, C J Der

Oncogene 10.1038/onc.2013.362

[10]

10.1126/scisignal.2003543

[11]

10.1016/s0092-8674(00)80670-4

[12]

10.1038/nrm3153

[13]

10.1080/21541248.2016.1232583

[14]

10.1038/ncb2112

[15]

10.1016/j.tcb.2012.04.004

[16]

Adnane J Clin Cancer Res (2002)

[17]

10.1002/ijc.22328

[18]

10.1038/sj.bjc.6600510

[19]

10.3390/cells8091063

[20]

10.1016/j.jocn.2004.08.013

[21]

10.1186/1471-2407-13-63

[22]

10.7150/jca.18161

[23]

10.1042/bj3480241

[24]

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

Mutsuki Amano, Masaaki Ito, Kazushi Kimura et al.

Journal of Biological Chemistry 10.1074/jbc.271.34.20246

[25]

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

Kazushi Kimura, Masaaki Ito, Mutsuki Amano et al.

Science 10.1126/science.273.5272.245

[26]

10.1038/onc.2016.454

[27]

10.1016/j.canlet.2019.08.011

[28]

10.1038/ncb1973

[29]

10.1038/ncb1675

[30]

10.1016/j.cell.2008.09.043

[31]

10.1016/j.molcel.2012.05.007

[32]

10.3389/fcell.2020.00201

[33]

10.1038/onc.2014.328

[34]

10.1016/j.febslet.2009.05.007

[35]

10.1002/bies.20238

[36]

10.1158/1078-0432.ccr-0436-03

[37]

10.1016/j.bbamcr.2019.118570

[38]

10.1016/j.ccell.2019.05.015

[39]

10.1128/mcb.15.11.6443

[40]

10.1093/emboj/17.5.1350

[41]

10.1038/nature13480

[42]

10.1038/ng.2984

[43]

10.1038/ng.2983

[44]

10.1038/ng.2873

[45]

10.1038/ng.2872

[46]

10.1038/ng.2916

[47]

10.1038/onc.2015.442

[48]

10.1182/blood-2015-06-644948

[49]

10.1038/s41388-019-0963-7

[50]

10.1126/science.aba8347

Showing 50 of 553 references

Cited By

228

Rho-GTPases subfamily: cellular defectors orchestrating viral infection

Beibei Zhang, Shuli Li · 2025

Cellular & Molecular Biology Le...

Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS

Guowei Yin, Jing Huang · 2023

Signal Transduction and Targeted Th...

Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities

Siyi Li, Chibuzo Sampson · 2023

Cell Communication and Signaling

Biochemical Pathways of Cellular Mechanosensing/Mechanotransduction and Their Role in Neurodegenerative Diseases Pathogenesis

Ilaria Tortorella, Chiara Argentati · 2022

Cells

Metrics

228

Citations

553

References

Details

Published: Jan 01, 2022
Vol/Issue: 102(1)
Pages: 455-510

Authors

E

Eva Crosas-Molist