Circadian clocks of the kidney: function, mechanism, and regulation

Hannah M. Costello; Jermaine G. Johnston; Alexandria Juffre; G. Ryan Crislip; Michelle L. Gumz

doi:10.1152/physrev.00045.2021

journal article Oct 01, 2022

Circadian clocks of the kidney: function, mechanism, and regulation

Hannah M. Costello Jermaine G. Johnston Alexandria Juffre G. Ryan Crislip Michelle L. Gumz

Physiological Reviews Vol. 102 No. 4 pp. 1669-1701 · American Physiological Society

View at Publisher Save 10.1152/physrev.00045.2021

Abstract

An intrinsic cellular circadian clock is located in nearly every cell of the body. The peripheral circadian clocks within the cells of the kidney contribute to the regulation of a variety of renal processes. In this review, we summarize what is currently known regarding the function, mechanism, and regulation of kidney clocks. Additionally, the effect of extrarenal physiological processes, such as endocrine and neuronal signals, on kidney function is also reviewed. Circadian rhythms in renal function are an integral part of kidney physiology, underscoring the importance of considering time of day as a key biological variable. The field of circadian renal physiology is of tremendous relevance, but with limited physiological and mechanistic information on the kidney clocks this is an area in need of extensive investigation.

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Details

Published: Oct 01, 2022
Vol/Issue: 102(4)
Pages: 1669-1701

Authors

H

Hannah M. Costello

Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida; Division of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida

J

Jermaine G. Johnston

Division of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida; North Florida/South Georgia Malcom Randall Department of Veterans Affairs Medical Center, Gainesville, Florida

A

Alexandria Juffre

Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida; Division of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida

G

G. Ryan Crislip

Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida; Division of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida

M

Michelle L. Gumz

Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida; Division of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida; North Florida/South Georgia Malcom Randall Department of Veterans Affairs Medical Center, Gainesville, Florida; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida; Center for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, Florida

Funding

American Heart Association Award: 19EIA34660135

Cite This Article

Hannah M. Costello, Jermaine G. Johnston, Alexandria Juffre, et al. (2022). Circadian clocks of the kidney: function, mechanism, and regulation. Physiological Reviews, 102(4), 1669-1701. https://doi.org/10.1152/physrev.00045.2021

Circadian clocks of the kidney: function, mechanism, and regulation

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