Electrospray Ionization Mass Spectrometry: A Technique to Access the Information beyond the Molecular Weight of the Analyte

Shibdas Banerjee; Shyamalava Mazumdar

doi:10.1155/2012/282574

journal article Open Access Jan 01, 2012

Electrospray Ionization Mass Spectrometry: A Technique to Access the Information beyond the Molecular Weight of the Analyte

Shibdas Banerjee

Shyamalava Mazumdar

International Journal of Analytical Chemistry Vol. 2012 pp. 1-40 · Wiley

View at Publisher Save 10.1155/2012/282574

Abstract

The Electrospray Ionization (ESI) is a soft ionization technique extensively used for production of gas phase ions (without fragmentation) of thermally labile large supramolecules. In the present review we have described the development of Electrospray Ionization mass spectrometry (ESI-MS) during the last 25 years in the study of various properties of different types of biological molecules. There have been extensive studies on the mechanism of formation of charged gaseous species by the ESI. Several groups have investigated the origin and implications of the multiple charge states of proteins observed in the ESI-mass spectra of the proteins. The charged analytes produced by ESI can be fragmented by activating them in the gas-phase, and thus tandem mass spectrometry has been developed, which provides very important insights on the structural properties of the molecule. The review will highlight recent developments and emerging directions in this fascinating area of research.

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References

Details

Published: Jan 01, 2012
Vol/Issue: 2012
Pages: 1-40
License: View

Authors

S

Shibdas Banerjee

Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India

S

Shyamalava Mazumdar

Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400005, India

Funding

Tata Institute of Fundamental Research, India

Cite This Article

Shibdas Banerjee, Shyamalava Mazumdar (2012). Electrospray Ionization Mass Spectrometry: A Technique to Access the Information beyond the Molecular Weight of the Analyte. International Journal of Analytical Chemistry, 2012, 1-40. https://doi.org/10.1155/2012/282574

Electrospray Ionization Mass Spectrometry: A Technique to Access the Information beyond the Molecular Weight of the Analyte

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