Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging

A. Greco; M. Mancini; S. Gargiulo; M. Gramanzini; P. P. Claudio; A. Brunetti; M. Salvatore

doi:10.1155/2012/519238

journal article Open Access Jan 01, 2012

Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging

A. Greco

M. Mancini S. Gargiulo

M. Gramanzini P. P. Claudio A. Brunetti M. Salvatore

Journal of Biomedicine and Biotechnology Vol. 2012 pp. 1-14 · Hindawi Limited

View at Publisher Save 10.1155/2012/519238

Abstract

Ultrasound biomicroscopy (UBM) is a noninvasive multimodality technique that allows high-resolution imaging in mice. It is affordable, widely available, and portable. When it is coupled to Doppler ultrasound with color and power Doppler, it can be used to quantify blood flow and to image microcirculation as well as the response of tumor blood supply to cancer therapy. Target contrast ultrasound combines ultrasound with novel molecular targeted contrast agent to assess biological processes at molecular level. UBM is useful to investigate the growth and differentiation of tumors as well as to detect early molecular expression of cancer-related biomarkersin vivoand to monitor the effects of cancer therapies. It can be also used to visualize the embryological development of mice in uterus or to examine their cardiovascular development. The availability of real-time imaging of mice anatomy allows performing aspiration procedures under ultrasound guidance as well as the microinjection of cells, viruses, or other agents into precise locations. This paper will describe some basic principles of high-resolution imaging equipment, and the most important applications in molecular and preclinical imaging in small animal research.

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Published: Jan 01, 2012
Vol/Issue: 2012
Pages: 1-14
License: View

Authors

A

A. Greco

Department of Biomorphological and Functional Sciences, University of Naples “Federico II”, 80131 Naples, Italy; CEINGE-Biotecnologie Avanzate, s.c.ar.l., 80145 Naples, Italy; Institute of Biostructure and Bioimaging, Italian National Research Council (CNR), 80131 Naples, Italy

M

M. Mancini

Institute of Biostructure and Bioimaging, Italian National Research Council (CNR), 80131 Naples, Italy; SDN Foundation Instituto di Ricovero e Cura a Carattere Scientifico (M.M.), 80131 Naples, Italy

S

S. Gargiulo

Department of Biomorphological and Functional Sciences, University of Naples “Federico II”, 80131 Naples, Italy; CEINGE-Biotecnologie Avanzate, s.c.ar.l., 80145 Naples, Italy

M

M. Gramanzini

CEINGE-Biotecnologie Avanzate, s.c.ar.l., 80145 Naples, Italy; Institute of Biostructure and Bioimaging, Italian National Research Council (CNR), 80131 Naples, Italy

P

P. P. Claudio

Department of Biochemistry and Microbiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA; Department of Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA

A

A. Brunetti

Department of Biomorphological and Functional Sciences, University of Naples “Federico II”, 80131 Naples, Italy; CEINGE-Biotecnologie Avanzate, s.c.ar.l., 80145 Naples, Italy; Institute of Biostructure and Bioimaging, Italian National Research Council (CNR), 80131 Naples, Italy

M

M. Salvatore

Department of Biomorphological and Functional Sciences, University of Naples “Federico II”, 80131 Naples, Italy; SDN Foundation Instituto di Ricovero e Cura a Carattere Scientifico (M.M.), 80131 Naples, Italy

Cite This Article

A. Greco, M. Mancini, S. Gargiulo, et al. (2012). Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging. Journal of Biomedicine and Biotechnology, 2012, 1-14. https://doi.org/10.1155/2012/519238

Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging

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