A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women

Elena Benelli; Scilla Del Ghianda; Caterina Di Cosmo; Massimo Tonacchera

doi:10.1155/2016/3204083

journal article Open Access Jan 01, 2016

A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women

Elena Benelli Scilla Del Ghianda Caterina Di Cosmo

Massimo Tonacchera

International Journal of Endocrinology Vol. 2016 pp. 1-5 · Wiley

View at Publisher Save 10.1155/2016/3204083

Abstract

Introduction.We evaluated the effects of a therapy that combines myo-inositol (MI) and D-chiro-inositol (DCI) in young overweight women affected by polycystic ovary syndrome (PCOS), characterized by oligo- or anovulation and hyperandrogenism, correlated to insulin resistance.Methods.We enrolled 46 patients affected by PCOS and, randomly, we assigned them to two groups, A and B, treated, respectively, with the association of MI plus DCI, in a 40 : 1 ratio, or with placebo (folic acid) for six months. Thus, we analyzed pretreatment and posttreatment FSH, LH, 17-beta-Estradiol, Sex Hormone Binding Globulin, androstenedione, free testosterone, dehydroepiandrosterone sulphate, HOMA index, and fasting glucose and insulin.Results.We recorded a statistically significant reduction of LH, free testosterone, fasting insulin, and HOMA index only in the group treated with the combined therapy of MI plus DCI; in the same patients, we observed a statistically significant increase of 17-beta-Estradiol levels.Conclusions.The combined therapy of MI plus DCI is effective in improving endocrine and metabolic parameters in young obese PCOS affected women.

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References

43

[1]

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome

Fertility and Sterility 10.1016/j.fertnstert.2003.10.004

[2]

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)

Human Reproduction 2004 10.1093/humrep/deh098

[3]

10.2147/clep.s37559

[4]

10.1111/j.1365-2265.2006.02587.x

[5]

10.3109/09513590.2015.1009437

[6]

10.1210/jcem-50-1-113

[7]

(1988)

[8]

10.1210/er.18.6.774

[9]

10.1016/s0026-0495(99)90028-8

[10]

10.1016/s1575-0922(06)71168-8

[11]

10.1001/archinte.166.19.2081

[12]

10.1093/humrep/des463

[13]

Endocrinology and Metabolism Clinics of North America (1991) 10.1016/s0889-8529(18)30245-7

[14]

10.1016/j.fertnstert.2011.11.036

[15]

10.1016/s0015-0282(01)02963-6

[16]

10.1093/humrep/del185

[17]

10.1080/15604280212528

[18]

10.1080/09513590801893232

[19]

European Review for Medical and Pharmacological Sciences (2003)

[20]

European Review for Medical and Pharmacological Sciences (2014)

[21]

10.3109/09513590.2011.564685

[22]

10.1177/1933719113518985

[23]

10.1507/endocrj.ej13-0423

[24]

(2015)

[25]

10.3109/09513590.2015.1006616

[26]

10.1016/j.ejogrb.2015.09.024

[27]

10.1097/00003081-200306000-00011

[28]

10.1055/s-2007-1016294

[29]

10.1016/j.fertnstert.2003.05.020

[30]

10.3109/09513590.2011.650660

[31]

10.1016/j.fertnstert.2006.04.011

[32]

Journal of the Pancreas (2002)

[33]

European Review for Medical and Pharmacological Sciences (2009)

[34]

European Review for Medical and Pharmacological Sciences (2007)

[35]

10.1007/s00404-014-3552-6

[36]

European Review for Medical and Pharmacological Sciences (2012)

[37]

European Review for Medical and Pharmacological Sciences (2013)

[38]

Endocrinology (1993) 10.1210/endo.132.2.8425485

[39]

10.1016/s0006-291x(02)00313-3

[40]

10.1016/j.fertnstert.2006.11.137

[41]

10.1111/j.1365-2265.2012.04415.x

[42]

10.1136/bmj.b2921

[43]

10.1097/aog.0b013e3181bd12cb

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Details

Published: Jan 01, 2016
Vol/Issue: 2016
Pages: 1-5
License: View

Authors

E

Elena Benelli

Department of Clinical and Experimental Medicine, Section of Endocrinology, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy

S

Scilla Del Ghianda

Department of Clinical and Experimental Medicine, Section of Endocrinology, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy

C

Caterina Di Cosmo

Department of Clinical and Experimental Medicine, Section of Endocrinology, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy

M

Massimo Tonacchera

Department of Clinical and Experimental Medicine, Section of Endocrinology, University Hospital of Pisa, Via Paradisa 2, 56124 Pisa, Italy

Cite This Article

Elena Benelli, Scilla Del Ghianda, Caterina Di Cosmo, et al. (2016). A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women. International Journal of Endocrinology, 2016, 1-5. https://doi.org/10.1155/2016/3204083

A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women

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