Contrast-Enhanced Computed Tomography Does Not Provide More Information about Sarcopenia than Unenhanced Computed Tomography in Patients with Pancreatic Cancer

Jiabin Liu; Fei Li; Feng Cao; Ang Li

doi:10.1155/2021/5546030

journal article Open Access Apr 23, 2021

Contrast-Enhanced Computed Tomography Does Not Provide More Information about Sarcopenia than Unenhanced Computed Tomography in Patients with Pancreatic Cancer

Jiabin Liu

Fei Li

Feng Cao

Ang Li

Contrast Media & Molecular Imaging Vol. 2021 pp. 1-8 · Wiley

View at Publisher Save 10.1155/2021/5546030

Abstract

Objective. The aim of this study was to understand whether enhanced CT can provide more information than unenhanced CT on diagnosis of sarcopenia. Materials and Methods. We reviewed the enhanced CT data of 45 patients of pancreatic cancer. Manual tracing of the psoas muscles was used for measuring the cross-sectional muscle areas and attenuation at umbilicus level; afterwards, PMI, PMD, and Δ PMD were calculated. Results. In the unenhanced scanning, arterial, venous, and parenchymal phases of enhanced CT, PMI values were 6.905 ± 2.170, 6.886 ± 2.195, 6.923 ± 2.239, and 6.866 ± 2.218, respectively, and the difference was not statistically significant. The PMD values at different phases were 34.311 ± 7.535, 37.487 ± 7.118, 40.689 ± 7.116, and 42.989 ± 7.745, respectively, which were gradually increased, and the difference was statistically significant. Meanwhile, the PMD of arterial phase, venous phase, and parenchyma phase showed a linear correlation with PMD of unenhanced scanning phase. 31 patients had low PMD and 14 had normal PMD during the unenhanced scanning phase. With the addition of contrast agent, ΔPMD values increased faster in the low PMD group than in the normal PMD group during the venous and parenchymal phases (7.048 ± 3.067 vs 4.893 ± 2.558; 9.581 ± 3.033 vs 6.679 ± 2.621;

p
<
0.05

), which made the gap between PMD after contrast-enhancement vs. unenhanced scanning smaller. Conclusion. The use of contrast agent has no effect on the manually measured PMI values but can change the results of PMD. This change makes the difference of PMD in different enhancement phases smaller than that in plain scan phase and furthermore increases the examination cost; therefore, it is not recommended to use enhanced CT routinely with fixed dose administration of contrast agent for patients’ assessment of PMI and PMD.

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References

Details

Published: Apr 23, 2021
Vol/Issue: 2021
Pages: 1-8
License: View

Authors

J

Jiabin Liu

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China

F

Fei Li

Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China

F

Feng Cao

Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China

A

Ang Li

Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China

Cite This Article

Jiabin Liu, Fei Li, Feng Cao, et al. (2021). Contrast-Enhanced Computed Tomography Does Not Provide More Information about Sarcopenia than Unenhanced Computed Tomography in Patients with Pancreatic Cancer. Contrast Media & Molecular Imaging, 2021, 1-8. https://doi.org/10.1155/2021/5546030

Contrast-Enhanced Computed Tomography Does Not Provide More Information about Sarcopenia than Unenhanced Computed Tomography in Patients with Pancreatic Cancer

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