Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration

Kangkang Zha; Zhiqiang Sun; Yu Yang; MingXue Chen; Cangjiang Gao; Liwei Fu; Hao Li; Xiang Sui; Quanyi Guo; Shuyun Liu

doi:10.1155/2021/8830834

journal article Open Access Mar 20, 2021

Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration

Kangkang Zha

Zhiqiang Sun

Yu Yang

MingXue Chen Cangjiang Gao Liwei Fu Hao Li

Xiang Sui Quanyi Guo

Shuyun Liu

Stem Cells International Vol. 2021 pp. 1-15 · Hindawi Limited

View at Publisher Save 10.1155/2021/8830834

Abstract

Articular cartilage is susceptible to damage, but its self-repair is hindered by its avascular nature. Traditional treatment methods are not able to achieve satisfactory repair effects, and the development of tissue engineering techniques has shed new light on cartilage regeneration. Mesenchymal stem cells (MSCs) are one of the most commonly used seed cells in cartilage tissue engineering. However, MSCs tend to lose their multipotency, and the composition and structure of cartilage-like tissues formed by MSCs are far from those of native cartilage. Thus, there is an urgent need to develop strategies that promote MSC chondrogenic differentiation to give rise to durable and phenotypically correct regenerated cartilage. This review provides an overview of recent advances in enhancement strategies for MSC chondrogenic differentiation, including optimization of bioactive factors, culture conditions, cell type selection, coculture, gene editing, scaffolds, and physical stimulation. This review will aid the further understanding of the MSC chondrogenic differentiation process and enable improvement of MSC-based cartilage tissue engineering.

Topics

No keywords indexed for this article. Browse by subject →

References

142

[1]

10.1016/j.drudis.2014.05.014

[2]

10.1177/0363546519887957

[3]

10.1177/1947603513515483

[4]

10.1177/2325967119872446

[5]

10.1177/0363546520920626

[6]

10.1177/0363546520908588

[7]

10.1155/2020/5690252

[8]

10.1016/j.jcyt.2019.10.004

[9]

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

M. Dominici, K. Le Blanc, I. Mueller et al.

Cytotherapy 10.1080/14653240600855905

[10]

Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation

Jaskarndip Chahal, Alejandro Gómez-Aristizábal, Konstantin Shestopaloff et al.

Stem Cells Translational Medicine 10.1002/sctm.18-0183

[11]

10.1038/s12276-018-0143-9

[12]

10.1089/ten.teb.2013.0771

[13]

10.1016/j.injury.2008.01.038

[14]

10.2174/157488812800793036

[15]

10.1016/j.pharmthera.2019.04.005

[16]

10.1182/blood-2007-07-103697

[17]

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

J. Massague

The EMBO Journal 10.1093/emboj/19.8.1745

[18]

10.3892/ijmm.2012.1107

[19]

10.1074/jbc.m305312200

[20]

10.1002/jcp.20977

[21]

10.1016/j.yexcr.2008.04.019

[22]

10.1111/cpr.12046

[23]

10.1002/stem.2120

[24]

10.1016/j.biotechadv.2015.08.005

[25]

10.1126/science.1215157

[26]

10.1016/j.msec.2017.07.005

[27]

10.3390/molecules23010181

[28]

10.1186/s11658-019-0144-2

[29]

10.1038/s41598-020-65283-8

[30]

10.4149/bll_2017_114

[31]

10.1111/os.12691

[32]

10.12659/msm.916696

[33]

10.1096/fj.201802137rrr

[34]

SERPINA9 and SERPINB2: Novel Cartilage Lineage Differentiation Markers of Human Mesenchymal Stem Cells with Kartogenin

Julio Granados-Montiel, Monica Cruz-Lemini, Claudia Rangel-Escareño et al.

CARTILAGE 10.1177/1947603518809403

[35]

10.1080/21691401.2017.1397000

[36]

10.1039/c9tb02754h

[37]

10.1038/1831821a0

[38]

10.1002/jcp.27090

[39]

10.1111/jpi.12133

[40]

10.1186/s13287-018-1114-8

[41]

10.1186/s13287-018-0892-3

[42]

10.1111/jpi.12098

[43]

10.1016/j.jbiosc.2010.10.002

[44]

10.5966/sctm.2015-0233

[45]

10.1016/j.matbio.2007.07.002

[46]

10.1016/j.biomaterials.2018.10.028

[47]

10.1186/s13287-017-0728-6

[48]

10.1016/j.jbiosc.2020.01.004

[49]

10.1016/j.msec.2015.01.082

[50]

10.1002/jor.24224

Showing 50 of 142 references

Cited By

55

Electrospun bioactive polymer biomaterials enriched with collagen and platelet-rich plasma as a platform for in vitro chondrogenic differentiation of human mesenchymal stem cells

Paulina Trzaskowska, Ewa Rybak · 2025

Frontiers in Bioengineering and Bio...

Metrics

55

Citations

142

References

Details

Published: Mar 20, 2021
Vol/Issue: 2021
Pages: 1-15
License: View

Authors

K

Kangkang Zha

Medical School of Chinese PLA, Beijing, China; Institute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing, China; School of Medicine, Nankai University, Tianjin, China

Z

Zhiqiang Sun

Medical School of Chinese PLA, Beijing, China; Institute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing, China; School of Medicine, Nankai University, Tianjin, China

Y

Yu Yang

The Second People’s Hospital of Guiyang, Guiyang, Guizhou, China

M

MingXue Chen

Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

C

Cangjiang Gao

Medical School of Chinese PLA, Beijing, China; Institute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing, China; School of Medicine, Nankai University, Tianjin, China

L

Liwei Fu

Medical School of Chinese PLA, Beijing, China; Institute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing, China; School of Medicine, Nankai University, Tianjin, China

H

Hao Li

Medical School of Chinese PLA, Beijing, China; Institute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing, China; School of Medicine, Nankai University, Tianjin, China

X

Xiang Sui

Institute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing, China

Q

Quanyi Guo

Institute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing, China

S

Shuyun Liu

Institute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing, China

Funding

National Natural Science Foundation of China Award: 81772319

National Key R&D Program of China Award: 81772319

Cite This Article

Kangkang Zha, Zhiqiang Sun, Yu Yang, et al. (2021). Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration. Stem Cells International, 2021, 1-15. https://doi.org/10.1155/2021/8830834

Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration

You May Also Like