The Role of Acupuncture Improving Cognitive Deficits due to Alzheimer’s Disease or Vascular Diseases through Regulating Neuroplasticity

Shaozhen Ji; Jiayu Duan; Xiaobing Hou; Li Zhou; Weilan Qin; Huanmin Niu; Shihan Luo; Yunling Zhang; Piu Chan; Xianglan Jin

doi:10.1155/2021/8868447

journal article Open Access Jan 12, 2021

The Role of Acupuncture Improving Cognitive Deficits due to Alzheimer’s Disease or Vascular Diseases through Regulating Neuroplasticity

Shaozhen Ji

Jiayu Duan Xiaobing Hou Li Zhou

Weilan Qin Huanmin Niu Shihan Luo

Yunling Zhang Piu Chan

Xianglan Jin

Neural Plasticity Vol. 2021 pp. 1-16 · Wiley

View at Publisher Save 10.1155/2021/8868447

Abstract

Dementia affects millions of elderly worldwide causing remarkable costs to society, but effective treatment is still lacking. Acupuncture is one of the complementary therapies that has been applied to cognitive deficits such as Alzheimer’s disease (AD) and vascular cognitive impairment (VCI), while the underlying mechanisms of its therapeutic efficiency remain elusive. Neuroplasticity is defined as the ability of the nervous system to adapt to internal and external environmental changes, which may support some data to clarify mechanisms how acupuncture improves cognitive impairments. This review summarizes the up-to-date and comprehensive information on the effectiveness of acupuncture treatment on neurogenesis and gliogenesis, synaptic plasticity, related regulatory factors, and signaling pathways, as well as brain network connectivity, to lay ground for fully elucidating the potential mechanism of acupuncture on the regulation of neuroplasticity and promoting its clinical application as a complementary therapy for AD and VCI.

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Details

Published: Jan 12, 2021
Vol/Issue: 2021
Pages: 1-16
License: View

Authors

S

Shaozhen Ji

Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China; Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China; National Clinical Research Center for Geriatric Disorders, Capital Medical University, Beijing 100053, China

J

Jiayu Duan

Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China; Beijing University of Chinese Medicine, Beijing 100029, China

X

Xiaobing Hou

Department of Neurology, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100039, China

L

Li Zhou

Department of Acupuncture and Moxibustion, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China

W

Weilan Qin

Department of Acupuncture and Moxibustion, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China

H

Huanmin Niu

Department of Neurology, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100039, China

S

Shihan Luo

Department of Neurology, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100039, China

Y

Yunling Zhang

Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China

P

Piu Chan

Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China; National Clinical Research Center for Geriatric Disorders, Capital Medical University, Beijing 100053, China

X

Xianglan Jin

Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China

Funding

Fundamental Research Funds for the Central Universities Award: 2021-JYB-XJSJJ071

National Key R&D Program of China Award: 2021-JYB-XJSJJ071

Beijing Municipal Science and Technology Commission Award: 2021-JYB-XJSJJ071

Talent Cultivation Plan for Inheritance of Clinical Characteristic Technology of Chinese Medicine Award: 2021-JYB-XJSJJ071

Cite This Article

Shaozhen Ji, Jiayu Duan, Xiaobing Hou, et al. (2021). The Role of Acupuncture Improving Cognitive Deficits due to Alzheimer’s Disease or Vascular Diseases through Regulating Neuroplasticity. Neural Plasticity, 2021, 1-16. https://doi.org/10.1155/2021/8868447

The Role of Acupuncture Improving Cognitive Deficits due to Alzheimer’s Disease or Vascular Diseases through Regulating Neuroplasticity

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