The Protective Effect of Cyanidin‐3‐Glucoside on Myocardial Ischemia‐Reperfusion Injury through Ferroptosis

Xin Shan; Zhi-Yang Lv; Meng-Jiao Yin; Jing Chen; Jie Wang; Qi-Nan Wu

doi:10.1155/2021/8880141

journal article Open Access Jan 01, 2021

The Protective Effect of Cyanidin‐3‐Glucoside on Myocardial Ischemia‐Reperfusion Injury through Ferroptosis

Xin Shan Zhi-Yang Lv

Meng-Jiao Yin Jing Chen

Jie Wang

Qi-Nan Wu

Oxidative Medicine and Cellular Longevity Vol. 2021 No. 1 · Wiley

View at Publisher Save 10.1155/2021/8880141

Abstract

This study was conducted to estimate the protective effect of Cyanidin‐3‐glucoside (C3G) on myocardial ischemia‐reperfusion (IR) injury and to explore its mechanism. The rats were subjected to left anterior descending ligation and perfusion surgery. In vitro experiments were performed on H9c2 cells using the oxygen‐glucose deprivation/reoxygenation (OGD/R) model. The results showed the administration of C3G reduced the infarction area, mitigated pathological alterations, inhibited ST segment elevation, and attenuated oxidative stress and ferroptosis‐related protein expression. C3G also suppressed the expressions of USP19, Beclin1, NCOA4, and LC3II/LC3I. In addition, treatment with C3G relieved oxidative stress, downregulated LC3II/LC3I, reduced autophagosome number, downregulated TfR1 expression, and upregulated the expressions of FTH1 and GPX4 in OGD/R‐induced H9c2 cells. C3G could inhibit the protein levels of USP19 and LC3II. C3G promoted K11‐linked ubiquitination of Beclin1. Further evidence that C3G reduced ferroptosis and ameliorated myocardial I/R injury was demonstrated with the ferroptosis promoter RSL3. Taken together, C3G could be a potential agent to protect myocardium from myocardial I/R injury.

Topics

No keywords indexed for this article. Browse by subject →

References

32

[1]

10.1016/j.bbrc.2018.05.004

[2]

10.1016/j.cell.2012.03.042

[3]

10.1073/pnas.1821022116

[4]

10.1093/cvr/cvr358

[5]

10.1016/j.yjmcc.2020.05.016

[6]

10.2147/ott.s240543

[7]

10.1096/fj.15-270579

[8]

10.3390/molecules21091264

[9]

10.1016/j.jff.2018.02.023

[10]

10.3390/medicina49020015

[11]

10.1016/j.numecd.2017.02.002

[12]

10.1039/c8fo00730f

[13]

10.1007/s00210-011-0665-3

[14]

10.1016/j.foodchem.2019.125980

[15]

10.1016/j.jhazmat.2019.121706

[16]

10.1007/s12012-013-9200-8

[17]

10.1089/ars.2010.3488

[18]

10.1172/jci132366

[19]

10.3892/mmr.2019.10228

[20]

HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury

Yanan Zhang, Dawei Liu, Haijuan Hu et al.

Biomedicine & Pharmacotherapy 10.1016/j.biopha.2019.109464

[21]

10.1038/embor.2009.69

[22]

10.1038/s41467-019-12145-1

[23]

10.1111/jcmm.15724

[24]

10.1007/s12192-020-01125-w

[25]

10.3233/jad-190635

[26]

10.1080/15548627.2019.1635381

[27]

10.1080/15548627.2016.1173801

[28]

10.1016/j.tips.2017.02.005

[29]

10.1073/pnas.1422373112

[30]

10.1007/s00018-016-2194-1

[31]

10.1038/s41419-019-2064-5

[32]

10.1089/dna.2019.5097

Cited By

123

Mechanisms of the RGS12-GPX4-ACSL4 signaling axis in regulating ferroptosis during myocardial ischemia-reperfusion injury

Congna Zi, Zhiwei Zhang · 2026

Journal of Anesthesia and Translati...

Iron homeostasis and ferroptosis in muscle diseases and disorders: mechanisms and therapeutic prospects

Qin Ru, Yusheng Li · 2025

Bone Research

Natural flavonoids act as potent ferroptosis inhibitors and their potentials in the treatment of ferroptosis-associated diseases

Lu Liu, Lun Wang · 2024

Pharmacological Research - Modern C...

Anti-Inflammatory and Anticancer Effects of Anthocyanins in In Vitro and In Vivo Studies

Tomasz Kowalczyk, Martyna Muskała · 2024

Antioxidants

Fang Yan, Kaifeng Li · 2022

Oxidative Medicine and Cellular Lon...

Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns

Johra Khan, Prashanta Kumar Deb · 2021

Molecules

Metrics

123

Citations

32

References

Details

Published: Jan 01, 2021
Vol/Issue: 2021(1)
License: View

Authors

China National GeneBank, Beijing Genomics Institute (BGI)–Shenzhen, Shenzhen, 518083, China.; BGI Education Center,University of Chinese Academy of Sciences,Shenzhen, 518083, China.

Q

Qi-Nan Wu

Funding

National Natural Science Foundation of China Award: 81973435

Cite This Article

Xin Shan, Zhi-Yang Lv, Meng-Jiao Yin, et al. (2021). The Protective Effect of Cyanidin‐3‐Glucoside on Myocardial Ischemia‐Reperfusion Injury through Ferroptosis. Oxidative Medicine and Cellular Longevity, 2021(1). https://doi.org/10.1155/2021/8880141

The Protective Effect of Cyanidin‐3‐Glucoside on Myocardial Ischemia‐Reperfusion Injury through Ferroptosis

You May Also Like